Racism-related developmental origins of mental health: a conceptual model and scoping review – Nature Mental Health

racism-related-developmental-origins-of-mental-health:-a-conceptual-model-and-scoping-review-–-nature-mental-health
  • Adams, L. M. & Miller, A. B. Mechanisms of mental-health disparities among minoritized groups: how well are the top journals in clinical psychology representing this work. Clin. Psychol. Sci. https://doi.org/10.1177/21677026211026979 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  • Breslau, J., Kendler, K. S., Su, M., Gaxiola-Aguilar, S. & Kessler, R. C. Lifetime risk and persistence of psychiatric disorders across ethnic groups in the United States. Psychol. Med. 35, 317–327 (2005).

    Article  PubMed  PubMed Central  Google Scholar 

  • Miranda, J., McGuire, T. G., Williams, D. R. & Wang, P. Mental health in the context of health disparities. Am. J. Psychiatry 165, 1102–1108 (2008).

    Article  PubMed  Google Scholar 

  • Alegría, M. et al. Prevalence, risk, and correlates of posttraumatic stress disorder across ethnic and racial minority groups in the United States. Med. Care 51, 1114–1123 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  • Vaeth, P. A. C., Wang-Schweig, M. & Caetano, R. Drinking, alcohol use disorder, and treatment access and utilization among U.S. racial/ethnic groups. Alcohol Clin. Exp. Res. 41, 6–19 (2017).

    Article  PubMed  Google Scholar 

  • Olbert, C. M., Nagendra, A. & Buck, B. Meta-analysis of black vs. white racial disparity in schizophrenia diagnosis in the United States: do structured assessments attenuate racial disparities?. J. Abnorm. Psychol. 127, 104–115 (2018).

    Article  PubMed  Google Scholar 

  • Baglivio, M. T., Wolff, K. T., Piquero, A. R., Greenwald, M. A. & Epps, N. Racial/ethnic disproportionality in psychiatric diagnoses and treatment in a sample of serious juvenile offenders. J. Youth Adolesc. 46, 1424–1451 (2017).

    Article  PubMed  Google Scholar 

  • Siegel, C. E., Laska, E. M., Wanderling, J. A., Hernandez, J. C. & Levenson, R. B. Prevalence and diagnosis rates of childhood ADHD among racial-ethnic groups in a public mental health system. Psychiatr. Serv. 67, 199–205 (2016).

    Article  PubMed  Google Scholar 

  • Rodriquez, E. J. et al. Relationships between allostatic load, unhealthy behaviors, and depressive disorder in U.S. adults, 2005–2012 NHANES. Prev. Med. 110, 9–15 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  • Boyd, R. W., Lindo, E. G., Weeks, L. D. & McLemore, M. R. On racism: a new standard for publishing on racial health inequities. Health Affairs Blog https://www.healthaffairs.org/do/10.1377/hblog20200630.939347/full/ (2020).

  • García, J. J. L. & Sharif, M. Z. Black lives matter: A commentary on racism and public health. Am. J. Public Health 105, e27 (2015).

    Article  Google Scholar 

  • Gee, G. C. & Ford, C. L. Structural racism and health inequities: old issues, new directions. Du Bois Rev. 8, 115–132 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  • Liu, S. R., Kia-Keating, M. & Nylund-Gibson, K. Patterns of adversity and pathways to health among white, Black, and Latinx youth. Child Abus. Negl. 86, 89–99 (2018).

    Article  Google Scholar 

  • Shonkoff, J. P., Slopen, N. & Williams, D. R. Early childhood adversity, toxic stress, and the impacts of racism on the foundations of health. Annu. Rev. Public Health 42, 115–134 (2020).

    Article  Google Scholar 

  • Williams, D. R. Stress and the mental health of populations of color: advancing our understanding of race-related stressors. J. Health Soc. Behav. 59, 466–485 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  • DuPont-Reyes, M. J., Villatoro, A. P., Phelan, J. C., Painter, K. & Link, B. G. Adolescent views of mental illness stigma: an intersectional lens. Am. J. Orthopsychiatry 90, 201–211 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  • Fripp, J. A. & Carlson, R. G. Exploring the influence of attitude and stigma on participation of African American and Latino populations in mental health services. J. Multicult. Couns. Dev. 45, 80–94 (2017).

    Article  Google Scholar 

  • Liang, J., Matheson, B. E. & Douglas, J. M. Mental health diagnostic considerations in racial/ethnic minority youth. J. Child Fam. Stud. 25, 1926–1940 (2016).

    Article  PubMed  Google Scholar 

  • Thomeer, M., Moody, M. & Yahirun, J. Racial and ethnic disparities in mental health and mental health care during the COVID-19 pandemic. J. Racial Ethn. Health Disparities https://doi.org/10.1007/s40615-022-01284-9 (2022).

  • Conradt, E., Carter, S. E. & Crowell, S. E. Biological embedding of chronic stress across two generations within marginalized communities. Child Dev. Perspect. 14, 208–214 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  • Liu, S. R., Sandman, C. A., Davis, E. P. & Glynn, L. M. Intergenerational risk and resilience pathways from discrimination and acculturative stress to infant mental health. Dev. Psychopathol. 35, 899–911 (2023).

    Article  PubMed  Google Scholar 

  • Liu, S. R. & Glynn, L. M. The contribution of racism-related stress and adversity to disparities in birth outcomes: evidence and research recommendations. FS Rep. 3, 5–13 (2022).

    Google Scholar 

  • Barker, D. J. P. The fetal and infant origins of adult disease. BMJ 301, 1111 (1990).

    Article  PubMed  PubMed Central  Google Scholar 

  • Barker, D. J. P. The origins of the developmental origins theory. J. Intern. Med. 261, 412–417 (2007).

    Article  PubMed  Google Scholar 

  • Cai, S. et al. Sleep quality and nocturnal sleep duration in pregnancy and risk of gestational diabetes mellitus. Sleep https://doi.org/10.1093/sleep/zsw058 (2017).

  • Hentges, R. F., Graham, S. A., Plamondon, A., Tough, S. & Madigan, S. A developmental cascade from prenatal stress to child internalizing and externalizing problems. J. Pediatr. Psychol. 44, 1057–1067 (2019).

    Article  PubMed  Google Scholar 

  • Davis, E. P. & Sandman, C. A. The timing of prenatal exposure to maternal cortisol and psychosocial stress is associated with human infant cognitive development. Child Dev. 81, 131–148 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  • Davis, E. P. & Sandman, C. A. Prenatal psychobiological predictors of anxiety risk in preadolescent children. Psychoneuroendocrinology 37, 1224–1233 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  • Essau, C. A., Sasagawa, S., Lewinsohn, P. M. & Rohde, P. The impact of pre- and perinatal factors on psychopathology in adulthood. J. Affect. Disord. 236, 52–59 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  • Glynn, L. M. et al. Prenatal maternal mood patterns predict child temperament and adolescent mental health. J. Affect. Disord. 228, 83–90 (2018).

    Article  PubMed  Google Scholar 

  • Graignic-Philippe, R., Dayan, J., Chokron, S., Jacquet, A. Y. & Tordjman, S. Effects of prenatal stress on fetal and child development: a critical literature review. Neurosci. Biobehav. Rev. 43, 137–162 (2014).

    Article  PubMed  Google Scholar 

  • Hicks, L. M., Swales, D. A., Garcia, S. E., Driver, C. & Davis, E. P. Does prenatal maternal distress contribute to sex differences in child psychopathology? Curr. Psychiatry Rep. https://doi.org/10.1007/s11920-019-0992-5 (2019).

  • Racine, N. et al. Maternal psychosocial risk profiles in pregnancy: associations with postpartum maternal health and child outcomes. Clin. Psychol. Sci. 6, 783–796 (2018).

    Article  Google Scholar 

  • Beijers, R., Jansen, J., Riksen-Walraven, M. & de Weerth, C. Maternal prenatal anxiety and stress predict infant illnesses and health complaints. Pediatrics 126, e401 (2010).

    Article  PubMed  Google Scholar 

  • Brunst, K. J. et al. Impact of maternal lifetime interpersonal trauma on children’s asthma: mediation through maternal active asthma during pregnancy. Psychosom. Med. 79, 91–100 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  • Cheng, E. R. et al. Examining the link between women’s exposure to stressful life events prior to conception and infant and toddler health: the role of birth weight. J. Epidemiol. Community Health 70, 245–252 (2016).

    Article  PubMed  Google Scholar 

  • Farewell, C. V., Puma, J., Thayer, Z. M. & Morton, S. Prenatal stress and early childhood body mass index: a path analysis approach. Matern. Child Health J. 25, 439–449 (2021).

    Article  PubMed  Google Scholar 

  • Gray, S. A. O., Jones, C. W., Theall, K. P., Glackin, E. & Drury, S. S. Thinking across generations: unique contributions of maternal early life and prenatal stress to infant physiology. J. Am. Acad. Child Adolesc. Psychiatry 56, 922–929 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  • Hanetz-Gamliel, K. & Dollberg, D. G. Links between mothers’ ACEs, their psychopathology and parenting, and their children’s behavior problems—a mediation model. Front. Psychiatry 13, 1064915 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  • Robinson, M. et al. Maternal prenatal stress exposure and sex-specific risk of severe infection in offspring. PLoS ONE 16, e0245747 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  • Spry, E. et al. Maternal mental health and infant emotional reactivity: a 20-year two-cohort study of preconception and perinatal exposures. Psychol. Med. 50, 827–837 (2020).

    Article  PubMed  Google Scholar 

  • Sternthal, M. J., Coull, B. A., Chiu, Y. H. M., Cohen, S. & Wright, R. J. Associations among maternal childhood socioeconomic status, cord blood IgE levels, and repeated wheeze in urban children. J. Allergy Clin. Immunol. 128, 337–345.e1 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  • Brown, J., Cohen, P., Johnson, J. G. & Smailes, E. M. Childhood abuse and neglect: specificity of effects on adolescent and young adult depression and suicidality. J. Am. Acad. Child. Adolesc. Psychiatry 38, 1490–1496 (1999).

  • Busso, D. S. et al. Child abuse, neural structure, and adolescent psychopathology: a longitudinal study. J. Am. Acad. Child Adolesc. Psychiatry 56, 321–328.e1 (2017).

  • Chiang, J. J., Lam, P. H., Chen, E. & Miller, G. E. Psychological stress during childhood and adolescence and its association with inflammation across the lifespan: a critical review and meta-analysis. Psychol. Bull. 148, 27–66 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  • Green, J. G. et al. Childhood adversities and adult psychiatric disorders in the National Comorbidity Survey Replication I: associations with first onset of DSM-IV disorders. Arch. Gen. Psychiatry 67, 113 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  • Harvanek, Z. M. et al. Childhood adversity, accelerated GrimAge, and associated health consequences. J. Behav. Med. https://doi.org/10.1007/s10865-024-00496-0 (2024).

  • Kessler, R. C. et al. Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys. Br. J. Psychiatry 197, 378–385 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  • Lee, R. Y., Oxford, M. L., Sonney, J., Enquobahrie, D. A. & Cato, K. D. Relationships between recent adverse childhood experiences (ACEs) and somatic symptoms in adolescence. J. Child Fam. Stud. 33, 1015–1028 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  • LeMoult, J. et al. Meta-analysis: exposure to early life stress and risk for depression in childhood and adolescence. J. Am. Acad. Child Adolesc. Psychiatry 59, 842–855 (2020).

  • McLaughlin, K. A., Conron, K. J., Koenen, K. C. & Gilman, S. E. Childhood adversity, adult stressful life events, and risk of past-year psychiatric disorder: a test of the stress sensitization hypothesis in a population-based sample of adults. Psychol. Med. 40, 1647–1658 (2010).

  • McLaughlin, K. A. et al. Childhood adversities and first onset of psychiatric disorders in a national sample of US adolescents. Arch. Gen. Psychiatry 69, 1151 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  • Short, A. K. et al. Individual longitudinal changes in DNA-methylome identify signatures of early-life adversity and correlate with later outcome. Neurobiol. Stress. 31, 100652 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  • O’Brien, J. A., Lewkowitz, A. K., Main, E. K. & Adashi, E. Y. The ongoing U.S. struggle with maternal mortality. Am. J. Perinatol. 42, 1109–1118 (2025).

    Article  PubMed  Google Scholar 

  • Huang, R. S., Spence, A. R. & Abenhaim, H. A. Racial disparities in national maternal mortality trends in the United States from 2000 to 2019: a population-based study on 80 million live births. Arch. Gynecol. Obstet. 309, 1315–1322 (2023).

    Article  PubMed  Google Scholar 

  • Howell, E. A. Reducing disparities in severe maternal morbidity and mortality. Clin. Obstet. Gynecol. 61, 387–399 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  • Hailu, E. M., Maddali, S. R., Snowden, J. M., Carmichael, S. L. & Mujahid, M. S. Structural racism and adverse maternal health outcomes: a systematic review. Health Place. 78, 102923 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  • Saluja, B. & Bryant, Z. How implicit bias contributes to racial disparities in maternal morbidity and mortality in the United States. J. Womens Health 30, 270–273 (2021).

    Article  Google Scholar 

  • Alexander, M. The New Jim Crow: Mass Incarceration in the Age of Colorblindness revised edn (New Press, 2012).

  • Brondolo, E. et al. Stress and Health Disparities Report: Contexts, Mechanisms, and Interventions among Racial/Ethnic Minority and Low Socioeconomic Status Populations (American Psychological Association, 2017).

  • National Research Council. The Growth of Incarceration in the United States: Exploring Causes and Consequences 1st edn (National Academies Press, 2014); https://doi.org/10.17226/18613

  • Desmond, M. Evicted: Poverty and Profit in the American City (Crown, 2016).

  • Mohai, P. & Saha, R. Which came first, people or pollution? Assessing the disparate siting and post-siting demographic change hypotheses of environmental injustice. Environ. Res. Lett. 10, 115008 (2015).

    Article  Google Scholar 

  • Namin, S., Xu, W., Zhou, Y. & Beyer, K. The legacy of the Home Owners’ Loan Corporation and the political ecology of urban trees and air pollution in the United States. Soc. Sci. Med. 246, 112758 (2020).

    Article  PubMed  Google Scholar 

  • Poulson, M., Neufeld, M. Y., Dechert, T., Allee, L. & Kenzik, K. M. Historic redlining, structural racism, and firearm violence: a structural equation modeling approach. Lancet Regional Health Am. 3, 100052 (2021).

    Article  Google Scholar 

  • Shonkoff, J. P., Boyce, W. T. & McEwen, B. S. Neuroscience, molecular biology, and the childhood roots of health disparities: building a new framework for health promotion and disease prevention. JAMA 301, 2252 (2009).

    Article  PubMed  Google Scholar 

  • Benjet, C., Borges, G. & Medina-Mora, M. E. Chronic childhood adversity and onset of psychopathology during three life stages: childhood, adolescence and adulthood. J. Psychiatr. Res. 44, 732–740 (2010).

    Article  PubMed  Google Scholar 

  • Johnson, S. & Marlow, N. Preterm Birth and childhood psychiatric disorders. Pediatr. Res. 69, 11R–18R (2011).

    Article  PubMed  Google Scholar 

  • Leis, J. A., Heron, J., Stuart, E. A. & Mendelson, T. Associations Between maternal mental health and child emotional and behavioral problems: does prenatal mental health matter. J. Abnorm. Child Psychol. 42, 161–171 (2014).

    Article  PubMed  Google Scholar 

  • Van Lieshout, R. J. et al. Trajectories of psychopathology in extremely low birth weight survivors from early adolescence to adulthood: a 20-year longitudinal study. Child Psychol. Psychiatry 59, 1192–1200 (2018).

    Article  Google Scholar 

  • Wang, W. C. et al. Maternal adherence to healthy lifestyle and risk of depressive symptoms in the offspring: mediation by offspring lifestyle. Psychol. Med. 53, 6068–6076 (2023).

    Article  PubMed  Google Scholar 

  • Bailey, Z. D. et al. Structural racism and health inequities in the USA: evidence and interventions. Lancet 389, 1453–1463 (2017).

    Article  PubMed  Google Scholar 

  • Tricco, A. et al. PRISMA Extension for Scoping Reviews (PRISMA-ScR): checklist and explanation. Ann. Intern. Med. 169, 467–473 (2018).

    Article  PubMed  Google Scholar 

  • Forbes, M. K., Rapee, R. M., Camberis, A. L. & McMahon, C. A. Unique associations between childhood temperament characteristics and subsequent psychopathology symptom trajectories from childhood to early adolescence. J. Abnorm. Child Psychol. 45, 1221–1233 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  • Jovanovic, T. & Norrholm, S. D. Neural mechanisms of impaired fear inhibition in posttraumatic stress disorder. Front. Behav. Neurosci. https://doi.org/10.3389/fnbeh.2011.00044 (2011).

  • Memmott-Elison, M. K. & Toseeb, U. Prosocial behavior and psychopathology: an 11-year longitudinal study of inter- and intraindividual reciprocal relations across childhood and adolescence. Dev. Psychopathol. 35, 1982–1996 (2023).

    Article  PubMed  Google Scholar 

  • Mikulincer, M. & Shaver, P. R. An attachment perspective on psychopathology. World Psychiatry 11, 11–15 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  • Braithwaite, E. C. et al. Maternal prenatal cortisol predicts infant negative emotionality in a sex-dependent manner. Physiol. Behav. 175, 31–36 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  • Clayborne, Z. M. et al. Prenatal maternal stress, child internalizing and externalizing symptoms, and the moderating role of parenting: findings from the Norwegian mother, father, and child cohort study. Psychol. Med. https://doi.org/10.1017/s0033291721004311 (2021).

  • Glynn, L. M. & Sandman, C. A. Sex moderates associations between prenatal glucocorticoid exposure and human fetal neurological development. Dev. Sci. 15, 601–610 (2012).

    Article  PubMed  Google Scholar 

  • McLaughlin, C. et al. Prenatal and childhood stress exposure and the sex specific response to psychosocial stress in adulthood. Psychoneuroendocrinology 125, 105109 (2021).

    Article  PubMed  Google Scholar 

  • Sandman, C. A., Class, Q. A., Glynn, L. M. & Davis, E. P. Neurobehavioral Disorders and Developmental Origins of Health and Disease (Elsevier, 2015); https://doi.org/10.1016/B978-0-12-801383-0.00013-X

  • Sandman, C. A., Glynn, L. M. & Davis, E. P. Is there a viability-vulnerability tradeoff? Sex differences in fetal programming. J. Psychosom. Res. 75, 327–335 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  • Daniel, S. et al. Prenatal and early childhood exposure to phthalates and childhood behavior at age 7 years. Environ. Int. 143, 105894 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  • Margolis, A. E. et al. Longitudinal effects of prenatal exposure to air pollutants on self-regulatory capacities and social competence. J. Child Psychol. Psychiatry 57, 851–860 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  • Perera, F. P. et al. Effect of prenatal exposure to airborne polycyclic aromatic hydrocarbons on neurodevelopment in the first 3 years of life among inner-city children. Environ. Health Perspect. 114, 1287–1292 (2006).

    Article  PubMed  PubMed Central  Google Scholar 

  • Perera, F. P. et al. Prenatal bisphenol A exposure and child behavior in an inner-city cohort. Environ. Health Perspect. 120, 1190–1194 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  • Perera, F. P. et al. Early-life exposure to polycyclic aromatic hydrocarbons and ADHD behavior problems. PLoS ONE 9, e111670 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  • Perera, F. P. et al. Bisphenol A exposure and symptoms of anxiety and depression among inner city children at 10-12 years of age. Environ. Res. 151, 195–202 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  • Perera, F. P. et al. Combined effects of prenatal exposure to polycyclic aromatic hydrocarbons and material hardship on child ADHD behavior problems. Environ. Res. 160, 506–513 (2018).

    Article  PubMed  Google Scholar 

  • Roen, E. L. et al. Bisphenol A exposure and behavioral problems among inner city children at 7–9 years of age. Environ. Res. 142, 739–745 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  • Wallace, E. R. et al. Prenatal exposure to polycyclic aromatic hydrocarbons is not associated with behavior problems in preschool and early school-aged children: a prospective multi-cohort study. Environ. Res. 216, 114759 (2023).

    Article  PubMed  Google Scholar 

  • Loftus, C. T. et al. Exposure to ambient air pollution and early childhood behavior: a longitudinal cohort study. Environ. Res. 183, 109075 (2020).

    Article  PubMed  Google Scholar 

  • Rahman, F. et al. Prenatal PM2.5 exposure and infant temperament at age 6 months: sensitive windows and sex-specific associations. Environ. Res. 206, 112583 (2022).

    Article  PubMed  Google Scholar 

  • Eskenazi, B. et al. Organophosphate pesticide exposure and neurodevelopment in young Mexican–American children. Environ. Health Perspect. 115, 792–798 (2007).

    Article  PubMed  PubMed Central  Google Scholar 

  • Rauh, V. et al. Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children. Pediatrics 118, e1845 (2006).

    Article  PubMed  PubMed Central  Google Scholar 

  • Sagiv, S. K. et al. Prenatal exposure to organophosphate pesticides and risk-taking behaviors in early adulthood. Environ. Health 21, 8 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  • Leech, S. L., Larkby, C. A., Day, R. & Day, N. L. Predictors and correlates of high levels of depression and anxiety symptoms among children at age 10. J. Am. Acad. Child Adolesc. Psychiatry 45, 223–230 (2006).

    Article  PubMed  Google Scholar 

  • Fuller, A., Messito, M. J., Mendelsohn, A. L., Oyeku, S. O. & Gross, R. S. Prenatal material hardships and infant regulatory capacity at 10 months old in low-income Hispanic mother–infant pairs. Acad. Pediatr. 18, 897–904 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  • Ahmad, S. I. et al. Maternal childhood trauma and prenatal stressors are associated with child behavioral health. J. Dev. Orig. Health Dis. 13, 483–493 (2022).

    Article  PubMed  Google Scholar 

  • Palmer, F. B. et al. Early adversity, socioemotional development, and stress in urban 1-year-old children. J. Pediatr. 163, 1733–1739.e1 (2013).

    Article  PubMed  Google Scholar 

  • Palmer, F. B. et al. Socio-demographic, maternal, and child indicators of socioemotional problems in 2-year-old children: a cohort study. Med. (Baltim.). 97, e11468 (2018).

    Article  Google Scholar 

  • Weiss, S. J. & Seed, M. S. Precursors of mental health problems for low birth weight children: the salience of family environment during the first year of life. Child Psychiatry Hum. Dev. 33, 3–27 (2002).

    Article  PubMed  Google Scholar 

  • Baker, B. H. et al. Maternal age at birth and child attention-deficit hyperactivity disorder: causal association or familial confounding. J. Child Psychol. Psychiatry 64, 299–310 (2023).

    Article  PubMed  Google Scholar 

  • Lin, B., Crnic, K. A., Luecken, L. J. & Gonzales, N. A. Ontogeny of emotional and behavioral problems in a low-income, Mexican American sample. Dev. Psychol. 53, 2245–2260 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  • Noroña-Zhou, A. et al. A multi-cohort examination of the independent contributions of maternal childhood adversity and pregnancy stressors to the prediction of children’s anxiety and depression. Res. Child Adolesc. Psychopathol. 51, 497–512 (2023).

    Article  PubMed  Google Scholar 

  • Okano, L., Ji, Y., Riley, A. W. & Wang, X. Maternal psychosocial stress and children’s ADHD diagnosis: a prospective birth cohort study. J. Psychosom. Obstet. Gynaecol. 40, 217–225 (2019).

    Article  PubMed  Google Scholar 

  • Bush, N. R. et al. Effects of pre- and postnatal maternal stress on infant temperament and autonomic nervous system reactivity and regulation in a diverse, low-income population. Dev. Psychopathol. 29, 1553–1571 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  • Boyd, R. C., Zayas, L. H. & McKee, M. D. Mother-infant interaction, life events and prenatal and postpartum depressive symptoms among urban minority women in primary care. Matern. Child Health J. 10, 139–148 (2006).

    Article  PubMed  Google Scholar 

  • Ahlfs-Dunn, S. M. & Huth-Bocks, A. C. Intimate partner violence and infant socioemotional development: the moderating effects of maternal trauma symptoms. Infant Ment. Health J. 35, 322–335 (2014).

    Article  PubMed  Google Scholar 

  • Leslie, C. E., Walsh, C. S. & Sullivan, T. N. Implications of intergenerational trauma: associations between caregiver ACEs and child internalizing symptoms in an urban African American sample. Psychol. Trauma. https://doi.org/10.1037/tra0001334 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  • Michl-Petzing, L. C., Handley, E. D., Sturge-Apple, M., Cicchetti, D. & Toth, S. L. Re-examining the ‘cycle of abuse’: parenting determinants among previously maltreated, low-income mothers. J. Fam. Psychol. 33, 742–752 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  • Moog, N. K. et al. Intergenerational transmission of the effects of maternal exposure to childhood maltreatment in the USA: a retrospective cohort study. Lancet Public Health 8, e226–e237 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  • Pear, V. A., Petito, L. C. & Abrams, B. The role of maternal adverse childhood experiences and race in intergenerational high-risk smoking behaviors. Nicotine Tob. Res. 19, 623–630 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  • Roubinov, D. et al. Intergenerational transmission of maternal childhood adversity and depression on children’s internalizing problems. J. Affect. Disord. 308, 205–212 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  • Shih, E. W. et al. A path model examination: maternal anxiety and parenting mediate the association between maternal adverse childhood experiences and children’s internalizing behaviors. Psychol. Med. 53, 112–122 (2023).

    Article  PubMed  Google Scholar 

  • Bosquet Enlow, M., Egeland, B., Carlson, E., Blood, E. & Wright, R. J. Mother–infant attachment and the intergenerational transmission of posttraumatic stress disorder. Dev. Psychopathol. 26, 41–65 (2014).

    Article  PubMed  Google Scholar 

  • Hendrix, C. L. et al. Prenatal distress links maternal early life adversity to infant stress functioning in the next generation. J. Psychopathol. Clin. Sci. 131, 117–129 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  • Narayan, A. J. et al. Intergenerational continuity of adverse childhood experiences in homeless families: unpacking exposure to maltreatment versus family dysfunction. Am. J. Orthopsychiatry 87, 3–14 (2017).

    Article  PubMed  Google Scholar 

  • Powers, A. et al. Intergenerational transmission of risk for PTSD symptoms in African American children: the roles of maternal and child emotion dysregulation. Psychol. Trauma 14, 1099–1106 (2022).

    Article  PubMed  Google Scholar 

  • Linde-Krieger, L. & Yates, T. M. Mothers’ History of child sexual abuse and child behavior problems: the mediating role of mothers’ helpless state of mind. Child Maltreat. 23, 376–386 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  • Martinez-Torteya, C., Bogat, G. A., Lonstein, J. S., Granger, D. A. & Levendosky, A. A. Exposure to intimate partner violence in utero and infant internalizing behaviors: moderation by salivary cortisol-alpha amylase asymmetry. Early Hum. Dev. 113, 40–48 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  • Ochoa, L. G., Fernandez, A., Lee, T. K., Estrada, Y. & Prado, G. The intergenerational impact of adverse childhood experiences on Hispanic families: the mediational roles of parental depression and parent–adolescent communication. Fam. Process. 61, 422–435 (2022).

    Article  PubMed  Google Scholar 

  • Osborne, K. R., Duprey, E. B., Caughy, M. O. & Oshri, A. Parents’ maltreatment histories, dimensions of emotion regulation, and connections to offspring self-regulation: a sex-specific transmission pathway. J. Psychopathol. Behav. Assess. 43, 717–729 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  • Russotti, J., Warmingham, J. M., Handley, E. D., Rogosch, F. A. & Cicchetti, D. Child maltreatment: an intergenerational cascades model of risk processes potentiating child psychopathology. Child Abuse Negl. https://doi.org/10.1016/j.chiabu.2020.104829 (2021).

  • Hatch, V., Swerbenski, H. & Gray, S. A. O. Family social support buffers the intergenerational association of maternal adverse childhood experiences and preschoolers’ externalizing behavior. Am. J. Orthopsychiatry 90, 489–501 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  • Rosenthal, L. et al. Intergenerational consequences: women’s experiences of discrimination in pregnancy predict infant social–emotional development at 6 months and 1 year. J. Dev. Behav. Pediatr. 39, 228–237 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  • Lin, B. et al. Infant temperament profiles, cultural orientation, and toddler behavioral and physiological regulation in Mexican–American families. Child Dev. 92, e1110 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  • Curci, S. G., Luecken, L. J., Perez, M. & White, R. M. B. Prenatal neighborhood ethnocultural context and the mental health of mothers and children in low-income Mexican American families. Child Dev. 92, 1785–1800 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  • Huffhines, L., Coe, J. L., Busuito, A., Seifer, R. & Parade, S. H. Understanding links between maternal perinatal posttraumatic stress symptoms and infant socioemotional and physical health. Infant Ment. Health J. 43, 474–492 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  • Guyon-Harris, K., Huth-Bocks, A., Lauterbach, D. & Janisse, H. Trajectories of maternal depressive symptoms across the birth of a child: associations with toddler emotional development. Arch. Women’s. Ment. Health 19, 153–165 (2016).

    Article  Google Scholar 

  • Level, R. A. et al. Within- and between-family transactions of maternal depression and child engagement in the first 2 years of life: role of prenatal maternal risk and tobacco use. Depress. Anxiety 38, 1279–1288 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  • Babineau, V. et al. Associations of maternal prenatal stress and depressive symptoms with childhood neurobehavioral outcomes in the ECHO cohort of the NICHD Fetal Growth Studies: fetal growth velocity as a potential mediator. J. Am. Acad. Child Adolesc. Psychiatry 61, 1155–1167 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  • Urizar, G. G. Jr & Muñoz, R. F. Role of maternal depression on child development: a prospective analysis from pregnancy to early childhood. Child Psychiatry Hum. Dev. 53, 502–514 (2022).

    Article  PubMed  Google Scholar 

  • Edwards, R. C. & Hans, S. L. Prenatal depressive symptoms and toddler behavior problems: the role of maternal sensitivity and child sex. Child Psychiatry Hum. Dev. 47, 696–707 (2016).

    Article  PubMed  Google Scholar 

  • Enoch, M. A. et al. A prospective cohort study of influences on externalizing behaviors across childhood: results from a nurse home visiting randomized controlled trial. J. Am. Acad. Child Adolesc. Psychiatry 55, 376–382 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  • Gray, R. F., Indurkhya, A. & McCormick, M. C. Prevalence, stability, and predictors of clinically significant behavior problems in low birth weight children at 3, 5, and 8 years of age. Pediatrics 114, 736–743 (2004).

    Article  PubMed  Google Scholar 

  • Hruschak, J. L., Palopoli, A. C., Thomason, M. E. & Trentacosta, C. J. Maternal-fetal attachment, parenting stress during infancy, and child outcomes at age 3 years. Infant Ment. Health J. 43, 681–694 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  • Mahrer, N. E. et al. Pregnancy anxiety in expectant mothers predicts offspring negative affect: the moderating role of acculturation. Early Hum. Dev. 141, 104932 (2020).

    Article  PubMed  Google Scholar 

  • Miller, W. B., Sable, M. R. & Csizmadia, A. Pregnancy wantedness and child attachment security: is there a relationship. Matern. Child Health J. 12, 478–487 (2008).

    Article  PubMed  Google Scholar 

  • Buckingham-Howes, S., Mazza, D., Wang, Y., Granger, D. A. & Black, M. M. Prenatal drug exposure and adolescent cortisol reactivity: association with behavioral concerns. J. Dev. Behav. Pediatr. 37, 565–572 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  • Delaney-Black, V. et al. Teacher-assessed behavior of children prenatally exposed to cocaine. Pediatrics 106, 782–791 (2000).

    Article  PubMed  Google Scholar 

  • Greenwald, M. K. et al. Teens with heavy prenatal cocaine exposure respond to experimental social provocation with escape not aggression. Neurotoxicol. Teratol. 33, 198–204 (2011).

    Article  PubMed  Google Scholar 

  • Min, M. O., Minnes, S., Kim, J. Y., Yoon, M. & Singer, L. T. Association of prenatal cocaine exposure, childhood maltreatment, and responses to stress in adolescence. Drug Alcohol Depend. 177, 93–100 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  • Min, M. O. et al. Developmental trajectories of externalizing behavior from ages 4 to 12: prenatal cocaine exposure and adolescent correlates. Drug Alcohol Depend. 192, 223–232 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  • Min, M. O., Minnes, S., Kim, S. K., Kim, J. Y. & Singer, L. T. Prenatal cocaine exposure and substance use disorder in emerging adulthood at age 21. Drug Alcohol Depend. 242, 109736 (2023).

    Article  PubMed  Google Scholar 

  • Minnes, S. et al. The effects of prenatal cocaine exposure on problem behavior in children 4–10 years. Neurotoxicol. Teratol. 32, 443–451 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  • Minnes, S. et al. Executive function in children with prenatal cocaine exposure (12–15 years). Neurotoxicol. Teratol. 57, 79–86 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  • Richardson, G. A., De Genna, N. M., Goldschmidt, L., Larkby, C. & Donovan, J. E. Prenatal cocaine exposure: direct and indirect associations with 21-year-old offspring substance use and behavior problems. Drug Alcohol Depend. 195, 121–131 (2019).

    Article  PubMed  Google Scholar 

  • Brook, D. W., Zhang, C., Rosenberg, G. & Brook, J. S. Maternal cigarette smoking during pregnancy and child aggressive behavior. Am. J. Addict. 15, 450–456 (2006).

    Article  PubMed  Google Scholar 

  • Cornelius, M. D., Leech, S. L., Goldschmidt, L. & Day, N. L. Prenatal tobacco exposure: is it a risk factor for early tobacco experimentation? Nicotine Tob. Res. 2, 45–52 (2000).

    Article  PubMed  Google Scholar 

  • Cornelius, M. D., Leech, S. L., Goldschmidt, L. & Day, N. L. Is prenatal tobacco exposure a risk factor for early adolescent smoking? A follow-up study. Neurotoxicol. Teratol. 27, 667–676 (2005).

    Article  PubMed  Google Scholar 

  • Cornelius, M. D., Goldschmidt, L., De Genna, N. M. & Day, N. L. Smoking during teenage pregnancies: effects on behavioral problems in offspring. Nicotine Tob. Res. 9, 739–750 (2007).

    Article  PubMed  PubMed Central  Google Scholar 

  • Cornelius, M. D. et al. Effects of prenatal cigarette smoke exposure on neurobehavioral outcomes in 10-year-old children of adolescent mothers. Neurotoxicol. Teratol. 33, 137–144 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  • Cornelius, M. D., Goldschmidt, L., De Genna, N. M. & Larkby, C. Long-term effects of prenatal cigarette smoke exposure on behavior dysregulation among 14-year-old offspring of teenage mothers. Matern. Child Health J. 16, 694–705 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  • De Genna, N. M., Goldschmidt, L., Richardson, G. A., Cornelius, M. D. & Day, N. L. Prenatal exposure to tobacco and cannabis, early cannabis initiation, and daily dual use of combustible cigarettes and cannabis during young adulthood. Addict. Behav. https://doi.org/10.1016/j.addbeh.2021.106820 (2021).

  • Eiden, R. D. et al. Pre- and postnatal tobacco and cannabis exposure and child behavior problems: Bidirectional associations, joint effects, and sex differences. Drug Alcohol Depend. 185, 82–92 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  • Goldschmidt, L., Cornelius, M. D. & Day, N. L. Prenatal cigarette smoke exposure and early initiation of multiple substance use. Nicotine Tob. Res. 14, 694–702 (2012).

    Article  PubMed  Google Scholar 

  • Van der Molen, E., Hipwell, A. E., Vermeiren, R. & Loeber, R. Maternal characteristics predicting young girls’ disruptive behavior. J. Clin. Child Adolesc. Psychol. 40, 179–190 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  • Wakschlag, L. S. & Hans, S. L. Maternal smoking during pregnancy and conduct problems in high-risk youth: a developmental framework. Dev. Psychopathol. 14, 351–369 (2002).

    Article  PubMed  Google Scholar 

  • Accornero, V. H., Morrow, C. E., Bandstra, E. S., Johnson, A. L. & Anthony, J. C. Behavioral outcome of preschoolers exposed prenatally to cocaine: role of maternal behavioral health. J. Pediatr. Psychol. 27, 259–269 (2002).

    Article  PubMed  PubMed Central  Google Scholar 

  • Accornero, V. H., Anthony, J. C., Morrow, C. E., Xue, L. & Bandstra, E. S. Prenatal cocaine exposure: an examination of childhood externalizing and internalizing behavior problems at age 7 years. Epidemiol. Psichiatr. Soc. 15, 20–29 (2006).

    Article  PubMed  PubMed Central  Google Scholar 

  • Kim, J. Y. et al. Self-reported mental health outcomes in prenatally cocaine exposed adolescents at 17 years of age. Neurotoxicol. Teratol. 94, 107132 (2022).

    Article  PubMed  Google Scholar 

  • O’Leary, C. C. et al. Suicidal ideation among urban nine and ten year olds. J. Dev. Behav. Pediatr. 27, 33–39 (2006).

    Article  PubMed  PubMed Central  Google Scholar 

  • Warner, T. D. et al. Predicting caregiver-reported behavior problems in cocaine-exposed children at 3 years. J. Dev. Behav. Pediatr. 27, 83–92 (2006).

    Article  PubMed  PubMed Central  Google Scholar 

  • Chu, E. K. et al. Behavior problems during early childhood in children with prenatal methamphetamine exposure. Pediatrics https://doi.org/10.1542/peds.2019-0270 (2020).

  • LaGasse, L. L. et al. Prenatal methamphetamine exposure and childhood behavior problems at 3 and 5 years of age. Pediatrics 129, 681–688 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  • Wilson, G. S., McCreary, R., Kean, J. & Baxter, J. C. The development of preschool children of heroin-addicted mothers: a controlled study. Pediatrics 63, 135–141 (1979).

    Article  PubMed  Google Scholar 

  • Bakhireva, L. N. et al. Role of caregiver-reported outcomes in identification of children with prenatal alcohol exposure during the first year of life. Pediatr. Res. 84, 362–370 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  • Cornelius, M. D., Goldschmidt, L. & Day, N. L. Gestational alcohol exposure and other factors associated with continued teenage drinking. Health Educ. Behav. 43, 428–433 (2016).

    Article  PubMed  Google Scholar 

  • Bailey, B. N. et al. Prenatal exposure to binge drinking and cognitive and behavioral outcomes at age 7 years. Am. J. Obstet. Gynecol. 191, 1037–1043 (2004).

    Article  PubMed  Google Scholar 

  • Brown, R. T. et al. Effects of prenatal alcohol exposure at school age. II. Attention and behavior. Neurotoxicol. Teratol. 13, 369–376 (1991).

    Article  PubMed  Google Scholar 

  • Hannigan, J. H. et al. A 14-year retrospective maternal report of alcohol consumption in pregnancy predicts pregnancy and teen outcomes. Alcohol 44, 583–594 (2010).

    Article  PubMed  Google Scholar 

  • Jacobson, J. L., Dodge, N. C., Burden, M. J., Klorman, R. & Jacobson, S. W. Number processing in adolescents with prenatal alcohol exposure and ADHD: differences in the neurobehavioral phenotype. Alcohol Clin. Exp. Res. 35, 431–442 (2011).

    Article  PubMed  Google Scholar 

  • Sood, B. et al. Prenatal alcohol exposure and childhood behavior at age 6 to 7 years: I. dose-response effect. Pediatrics 108, E34 (2001).

    Article  PubMed  Google Scholar 

  • Ettekal, I., Eiden, R. D., Nickerson, A. B., Molnar, D. S. & Schuetze, P. Developmental cascades to children’s conduct problems: the role of prenatal substance use, socioeconomic adversity, maternal depression and sensitivity, and children’s conscience. Dev. Psychopathol. 32, 85–103 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  • Garrison-Desany, H. M. et al. Individual and combined association between prenatal polysubstance exposure and childhood risk of attention-deficit/hyperactivity disorder. JAMA Netw. Open. 5, e221957 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  • Hofheimer, J. A. et al. Assessment of psychosocial and neonatal risk factors for trajectories of behavioral dysregulation among young children from 18 to 72 months of age. JAMA Netw. Open 6, e2310059 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  • Lester, B. M. et al. Infant neurobehavioral dysregulation: behavior problems in children with prenatal substance exposure. Pediatrics 124, 1355–1362 (2009).

    Article  PubMed  PubMed Central  Google Scholar 

  • Wang, Y. et al. Prenatal drug exposure, behavioral problems, and drug experimentation mong African-American urban adolescents. J. Adolesc. Health 55, 423–431 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  • Weiss, S. J., Seed, M. S. & Harris-Muchell, C. The contribution of fetal drug exposure to temperament: potential teratogenic effects on neuropsychiatric risk. J. Child Psychol. Psychiatry 48, 773–784 (2007).

    Article  PubMed  Google Scholar 

  • Yumoto, C., Jacobson, S. W. & Jacobson, J. L. Fetal substance exposure and cumulative environmental risk in an African American cohort. Child Dev. 79, 1761–1776 (2008).

    Article  PubMed  PubMed Central  Google Scholar 

  • Buka, S. L., Cannon, T. D., Torrey, E. F. & Yolken, R. H. Maternal exposure to herpes simplex virus and risk of psychosis among adult offspring. Biol. Psychiatry 63, 809–815 (2008).

    Article  PubMed  Google Scholar 

  • Kreniske, P. et al. Predictors of attempted suicide among youth living with perinatal HIV infection and perinatal HIV-exposed uninfected counterparts. J. Acquir. Immune Defic. Syndr. 88, 348–355 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  • Camerota, M. et al. Testing a cascade model linking prenatal inflammation to child executive function. Behav. Brain Res. 431, 113959 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  • Melough, M. M. et al. Greater gestational vitamin D status is associated with reduced childhood behavioral problems in the Environmental Influences on Child Health Outcomes Program. J. Nutr. 153, 1502–1511 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  • Chu, S. H. et al. Circulating levels of maternal vitamin D and risk of ADHD in offspring: results from the Vitamin D Antenatal Asthma Reduction Trial. Int J. Epidemiol. 51, 910–918 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  • Chawla, D. et al. Early prenatal vitamin D concentrations and social-emotional development in infants. J. Matern. Fetal Neonatal Med. 32, 1441–1448 (2019).

    Article  PubMed  Google Scholar 

  • Deardorff, J., Smith, L. H., Petito, L., Kim, H. & Abrams, B. F. Maternal prepregnancy weight and children’s behavioral and emotional outcomes. Am. J. Prev. Med. 53, 432–440 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  • Tanda, R. & Salsberry, P. J. Racial differences in the association between maternal prepregnancy obesity and children’s behavior problems. J. Dev. Behav. Pediatr. 35, 118–127 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  • Rizzo, T. A., Silverman, B. L., Metzger, B. E. & Cho, N. H. Behavioral adjustment in children of diabetic mothers. Acta Paediatr. 86, 969–974 (1997).

    Article  PubMed  Google Scholar 

  • Gao, L., Li, S., Yue, Y. & Long, G. Maternal age at childbirth and the risk of attention-deficit/hyperactivity disorder and learning disability in offspring. Front. Public Health 11, 923133 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  • Aushev, V. N. et al. Placental gene network modules are associated with maternal stress during pregnancy and infant temperament. FASEB J. 35, e21922 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  • Barroso, N. E., Hartley, C. M., Bagner, D. M. & Pettit, J. W. The effect of preterm birth on infant negative affect and maternal postpartum depressive symptoms: a preliminary examination in an underrepresented minority sample. Infant Behav. Dev. 39, 159–165 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  • Weiss, S. J., Seed, M. S. & Wilson, P. The temperament of pre-term, low birth weight infants and its potential biological substrates. Res. Nurs. Health 27, 392–402 (2004).

    Article  PubMed  Google Scholar 

  • Anda, R. F. et al. The enduring effects of abuse and related adverse experiences in childhood: a convergence of evidence from neurobiology and epidemiology. Eur. Arch. Psychiatry Clin. Neurosci. 256, 174–186 (2006).

    Article  PubMed  Google Scholar 

  • Felitti, V. J. et al. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults: the Adverse Childhood Experiences (ACE) Study. Am. J. Prev. Med. https://doi.org/10.1016/S0749-3797(98)00017-8 (1998).

    Article  PubMed  Google Scholar 

  • Felitti, V. J. & Anda, R. F. in The Hidden Epidemic: The Impact of Early Life Trauma on Health and Disease (eds Lanius, R. & Vermetten, E) (Cambridge Univ. Press, 2010).

  • Bernard, D. L. et al. Making the ‘C-ACE’ for a culturally-informed adverse childhood experiences framework to understand the pervasive mental health impact of racism on Black youth. J. Child Adolesc. Trauma. https://doi.org/10.1007/s40653-020-00319-9 (2020).

  • LaBrenz, C. A., O’Gara, J. L., Panisch, L. S., Baiden, P. & Larkin, H. Adverse childhood experiences and mental and physical health disparities: the moderating effect of race and implications for social work. Soc. Work Health Care 59, 588–614 (2020).

    Article  PubMed  Google Scholar 

  • Liu, S. R., Kia-Keating, M., Nylund-Gibson, K. & Barnett, M. L. Co-occurring youth profiles of adverse childhood experiences and protective factors: associations with health, resilience, and racial disparities. Am. J. Community Psychol. https://doi.org/10.1002/ajcp.12387 (2019).

  • Liu, S. R. et al. Pediatric ACES assessment within a collaborative practice model: implications for health equity. Am. J. Orthopsychiatry https://doi.org/10.1037/ort0000536 (2021).

  • Conway, C. A. & Lewin, A. Development and psychometric properties of the ACE-I: measuring adverse childhood experiences among Latino immigrant youth. Psychol. Trauma 14, 1247–1255 (2022).

    Article  PubMed  Google Scholar 

  • Cronholm, P. F. et al. Adverse childhood experiences: expanding the concept of adversity. Am. J. Prev. Med. 49, 354–361 (2015).

    Article  PubMed  Google Scholar 

  • Polanco-Roman, L. et al. Acculturation and suicide-related risk in ethnoracially minoritized youth in the US: a scoping review and content analysis of the empirical evidence. Soc. Psychiatry Psychiatr. Epidemiol. 58, 1121–1137 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  • Walker, R. L. Acculturation and acculturative stress as indicators for suicide risk among African Americans. Am. J. Orthopsychiatry 77, 386–391 (2007).

    Article  PubMed  Google Scholar 

  • Thornberry, T. P., Freeman-Gallant, A. & Lovegrove, P. J. The impact of parental stressors on the intergenerational transmission of antisocial behavior. J. Youth Adolesc. 38, 312–322 (2009).

    Article  PubMed  Google Scholar 

  • Day, N. L., Goldschmidt, L. & Thomas, C. A. Prenatal marijuana exposure contributes to the prediction of marijuana use at age 14. Addiction 101, 1313–1322 (2006).

    Article  PubMed  Google Scholar 

  • Goldschmidt, L., Day, N. L. & Richardson, G. A. Effects of prenatal marijuana exposure on child behavior problems at age 10. Neurotoxicol. Teratol. 22, 325–336 (2000).

    Article  PubMed  Google Scholar 

  • Goldschmidt, L., Richardson, G. A., Willford, J. A., Severtson, S. G. & Day, N. L. School achievement in 14-year-old youths prenatally exposed to marijuana. Neurotoxicol. Teratol. 34, 161–167 (2012).

    Article  PubMed  Google Scholar 

  • Richardson, G. A., Ryan, C., Willford, J., Day, N. L. & Goldschmidt, L. Prenatal alcohol and marijuana exposure: effects on neuropsychological outcomes at 10 years. Neurotoxicol. Teratol. 24, 309–320 (2002).

    Article  PubMed  Google Scholar 

  • Smid, M. C. et al. Prenatal nicotine or cannabis exposure and offspring neurobehavioral outcomes. Obstet. Gynecol. 139, 21–30 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  • Sonon, K. E., Richardson, G. A., Cornelius, J. R., Kim, K. H. & Day, N. L. Prenatal marijuana exposure predicts marijuana use in young adulthood. Neurotoxicol. Teratol. 47, 10–15 (2015).

    Article  PubMed  Google Scholar 

  • Eiden, R. D., Perry, K. J., Ivanova, M. Y. & Marcus, R. C. Prenatal substance exposure. Annu. Rev. Dev. Psychol. 5, 19–44 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  • Farahmand, P., Arshed, A. & Bradley, M. V. Systemic racism and substance use disorders. Psychiatr. Ann. 50, 494–498 (2020).

    Article  Google Scholar 

  • Compton, W. M., Einstein, E. B., Wargo, E. M., Crump, A. D. & Aklin, W. M. Racial inequities and addiction research. Drug Alcohol Depend. 251, 110940 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  • Gu, Z., Barch, D. M. & Luo, Q. Prenatal substance exposure and child health: understanding the role of environmental factors, genetics, and brain development. PNAS Nexus 3, pgae003 (2023).

    Article  Google Scholar 

  • Van Lieshout, R. J. et al. Impact of extremely low-birth-weight status on risk and resilience for depression and anxiety in adulthood. J. Child Psychol. Psychiatry 59, 596–603 (2018).

    Article  PubMed  Google Scholar 

  • Burlew, A. K., Peteet, B. J., McCuistian, C. & Miller-Roenigk, B. D. Best practices for researching diverse groups. Am. J. Orthopsychiatry 89, 354–368 (2019).

    Article  PubMed  Google Scholar 

  • Dordunoo, D., Abernethy, P., Kayuni, J., McConkey, S. & Aviles-G, M. L. Dismantling ‘race’ in health research. Can. J. Nurs. Res. 54, 239–245 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  • Buchanan, N. T., Perez, M., Prinstein, M. J. & Thurston, I. B. Upending racism in psychological science: strategies to change how science is conducted, reported, reviewed, and disseminated. Am. Psychol. 76, 1097–1112 (2021).

    Article  PubMed  Google Scholar 

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