Neuromodulation for treatment-resistant obsessive–compulsive disorder: a systematic review, meta-analysis and network analysis – Nature Mental Health

neuromodulation-for-treatment-resistant-obsessive–compulsive-disorder:-a-systematic-review,-meta-analysis-and-network-analysis-–-nature-mental-health
  • Cervin, M. Obsessive–compulsive disorder: diagnosis, clinical features, nosology, and epidemiology. Psychiatr. Clin. North Am. 46, 1–16 (2023).

    Article  PubMed  Google Scholar 

  • Goodman, W. K., Storch, E. A. & Sheth, S. A. Harmonizing the neurobiology and treatment of obsessive-compulsive disorder. Am. J. Psychiatry 178, 17–29 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  • Swierkosz-Lenart, K. et al. Therapies for obsessive–compulsive disorder: current state of the art and perspectives for approaching treatment-resistant patients. Front. Psychiatry 14, 1065812 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  • Robbins, T. W., Vaghi, M. M. & Banca, P. Obsessive–compulsive disorder: puzzles and prospects. Neuron 102, 27–47 (2019).

    Article  PubMed  Google Scholar 

  • Ahmari, S. E. & Rauch, S. L. The prefrontal cortex and OCD. Neuropsychopharmacology 47, 211–224 (2022).

    Article  PubMed  Google Scholar 

  • Rasmussen, S. A. & Goodman, W. K. The prefrontal cortex and neurosurgical treatment for intractable OCD. Neuropsychopharmacology 47, 349–360 (2022).

    Article  PubMed  Google Scholar 

  • Seamans, J. K. The anterior cingulate cortex and event-based modulation of autonomic states. Int. Rev. Neurobiol. 158, 135–169 (2021).

    Article  PubMed  Google Scholar 

  • Seamans, J. K. & Floresco, S. B. Event-based control of autonomic and emotional states by the anterior cingulate cortex. Neurosci. Biobehav. Rev. 133, 104503 (2022).

    Article  PubMed  Google Scholar 

  • Kumar, K. K. et al. Comparative effectiveness of neuroablation and deep brain stimulation for treatment-resistant obsessive–compulsive disorder: a meta-analytic study. J. Neurol. Neurosurg. Psychiatry 90, 469–473 (2019).

    Article  PubMed  Google Scholar 

  • Hageman, S. B. et al. Deep brain stimulation versus ablative surgery for treatment-refractory obsessive–compulsive disorder: a meta-analysis. Acta Psychiatr. Scand. 143, 307–318 (2021).

    Article  PubMed  Google Scholar 

  • Harmelech, T., Roth, Y. & Tendler, A. Transcranial magnetic stimulation in obsessive–compulsive disorder. Psychiatr. Clin. North Am. 46, 133–166 (2023).

    Article  PubMed  Google Scholar 

  • Brunelin, J. et al. Transcranial direct current stimulation for obsessive–compulsive disorder: a systematic review. Brain Sci. 8, 37 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  • Kricheldorff, J. et al. Evidence of neuroplastic changes after transcranial magnetic, electric, and deep brain stimulation. Brain Sci. 12, 929 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  • Siebner, H. R. et al. Transcranial magnetic stimulation of the brain: what is stimulated? A consensus and critical position paper. Clin. Neurophysiol. 140, 59–97 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  • Qiu, X., He, Z., Cao, X. & Zhang, D. Transcranial magnetic stimulation and transcranial direct current stimulation affect explicit but not implicit emotion regulation: a meta-analysis. Behav. Brain Funct. 19, 15 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  • Steuber, E. R. & McGuire, J. F. A meta-analysis of transcranial magnetic stimulation in obsessive–compulsive disorder. Biol. Psychiatry Cogn. Neurosci. Neuroimaging 8, 1145–1155 (2023).

    PubMed  Google Scholar 

  • Acevedo, N., Bosanac, P., Pikoos, T., Rossell, S. & Castle, D. Therapeutic neurostimulation in obsessive–compulsive and related disorders: a systematic review. Brain Sci. 11, 948 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  • Balachander, S., Arumugham, S. S. & Srinivas, D. Ablative neurosurgery and deep brain stimulation for obsessive–compulsive disorder. Indian J. Psychiatry 61, S77–S84 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  • Bourne, S. K., Eckhardt, C. A., Sheth, S. A. & Eskandar, E. N. Mechanisms of deep brain stimulation for obsessive–compulsive disorder: effects upon cells and circuits. Front. Integr. Neurosci. 6, 29 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  • Ibrahim, I. A. et al. A systematic review and meta-analysis for the efficacy of transcranial direct current stimulation (tDCS) in OCD treatment: a non-pharmacological approach to clinical interventions. Exp. Gerontol. 196, 112551 (2024).

    Article  PubMed  Google Scholar 

  • Senço, N. M. et al. Transcranial direct current stimulation in obsessive–compulsive disorder: emerging clinical evidence and considerations for optimal montage of electrodes. Expert Rev. Med. Devices 12, 381–391 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  • Robbins, T. W., Banca, P. & Belin, D. From compulsivity to compulsion: the neural basis of compulsive disorders. Nat. Rev. Neurosci. 25, 313–333 (2024).

    Article  PubMed  Google Scholar 

  • Doss, M. K. et al. Models of psychedelic drug action: modulation of cortical-subcortical circuits. Brain 145, 441–456 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  • Sieveritz, B. & Raghavan, R. T. The central thalamus: gatekeeper or processing hub? J. Neurosci. 41, 4954–4956 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  • Vaghi, M. M. et al. Specific frontostriatal circuits for impaired cognitive flexibility and goal-directed planning in obsessive–compulsive disorder: evidence from resting-state functional connectivity. Biol. Psychiatry 81, 708–717 (2017).

    Article  PubMed  Google Scholar 

  • Etkin, A., Egner, T. & Kalisch, R. Emotional processing in anterior cingulate and medial prefrontal cortex. Trends Cogn. Sci. 15, 85–93 (2011).

    Article  PubMed  Google Scholar 

  • Paulus, F. W., Ohmann, S., Möhler, E., Plener, P. & Popow, C. Emotional dysregulation in children and adolescents with psychiatric disorders. A narrative review. Front. Psychiatry 12, 628252 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  • Fitzgerald, K. D. et al. Altered function and connectivity of the medial frontal cortex in pediatric obsessive–compulsive disorder. Biol. Psychiatry 68, 1039–1047 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  • Bruin, W. B. et al. The functional connectome in obsessive–compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium. Mol. Psychiatry 28, 4307–4319 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  • Rădulescu, A., Herron, J., Kennedy, C. & Scimemi, A. Global and local excitation and inhibition shape the dynamics of the cortico–striatal–thalamo–cortical pathway. Sci. Rep. 7, 7608 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  • Philipson, J. et al. Deep brain stimulation in the ALIC-BNST region targeting the bed nucleus of stria terminalis in patients with obsessive–compulsive disorder: effects on cognition after 12 months. Acta Neurochir. 165, 1201–1214 (2023).

    Article  PubMed  Google Scholar 

  • Germann, J. et al. Brain structures and networks underlying treatment response to deep brain stimulation targeting the inferior thalamic peduncle in obsessive–compulsive disorder. Stereotact. Funct. Neurosurg. 100, 236–243 (2022).

  • Germann, J. et al. Potential optimization of focused ultrasound capsulotomy for obsessive compulsive disorder. Brain https://doi.org/10.1093/brain/awab232 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  • Hollunder, B. et al. Mapping dysfunctional circuits in the frontal cortex using deep brain stimulation. Nat. Neurosci. https://doi.org/10.1038/s41593-024-01570-1 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  • Gouveia, F. V. et al. Multi-centre analysis of networks and genes modulated by hypothalamic stimulation in patients with aggressive behaviours. Elife 12, e84566 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  • Germann, J., Gouveia, F. V., Beyn, M. E., Elias, G. J. B. & Lozano, A. M. in Computational Neurosurgery (eds Di Ieva, A. et al.) 435–451 (Springer Nature, 2024).

  • Germann, J. et al. Brain structures and networks responsible for stimulation-induced memory flashbacks during forniceal deep brain stimulation for Alzheimer’s disease. Alzheimers Dement. 17, 777–787 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  • Elias, G. et al. 3T MRI of rapid brain activity changes driven by subcallosal cingulate deep brain stimulation. Brain 145, 2214–2226 (2021).

    Article  Google Scholar 

  • Elias, G. J. B. et al. Local neuroanatomical and tract-based proxies of optimal subcallosal cingulate deep brain stimulation. Brain Stimul. https://doi.org/10.1016/j.brs.2023.08.014 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  • Carmi, L. et al. Clinical and electrophysiological outcomes of deep TMS over the medial prefrontal and anterior cingulate cortices in OCD patients. Brain Stimul. 11, 158–165 (2018).

    Article  PubMed  Google Scholar 

  • Carmi, L. et al. Efficacy and safety of deep transcranial magnetic stimulation for obsessive–compulsive disorder: a prospective multicenter randomized double-blind placebo-controlled trial. Am. J. Psychiatry 176, 931–938 (2019).

    Article  PubMed  Google Scholar 

  • Takroni, R. et al. Randomized controlled trials in neurosurgery. Surg. Neurol. Int. 13, 379 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  • Holtzheimer, P. E. et al. Subcallosal cingulate deep brain stimulation for treatment-resistant depression: a multisite, randomised, sham-controlled trial. Lancet Psychiatry 4, 839–849 (2017).

    Article  PubMed  Google Scholar 

  • Hamani, C. et al. Insertional effect following electrode implantation: an underreported but important phenomenon. Brain Commun. 6, fcae093 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  • Lozano, A. M. et al. Deep brain stimulation: current challenges and future directions. Nat. Rev. Neurol. 15, 148–160 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  • Cohen, P. D. et al. Sham neurosurgical procedures: the patients’ perspective. Lancet Neurol. 11, 1022 (2012).

    Article  PubMed  Google Scholar 

  • Vogt, G. S., Avendaño-Ortega, M., Schneider, S. C., Goodman, W. K. & Storch, E. A. Optimizing obsessive–compulsive symptom measurement with the Yale–Brown Obsessive–Compulsive Scales Second Edition. J. Psychiatr. Pract. 28, 294–309 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  • Mustroph, M. L., Cosgrove, G. R. & Williams, Z. M. The evolution of modern ablative surgery for the treatment of obsessive–compulsive and major depression disorders. Front. Integr. Neurosci. 16, 797533 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  • Jurcak, V., Okamoto, M., Singh, A. & Dan, I. Virtual 10–20 measurement on MR images for inter-modal linking of transcranial and tomographic neuroimaging methods. Neuroimage 26, 1184–1192 (2005).

    Article  PubMed  Google Scholar 

  • Holmes, N. P. et al. Locating primary somatosensory cortex in human brain stimulation studies: experimental evidence. J. Neurophysiol. 121, 336–344 (2019).

    Article  PubMed  Google Scholar 

  • Fonov, V. S., Evans, A. C., McKinstry, R. C., Almli, C. R. & Collins, D. L. Unbiased nonlinear average age-appropriate brain templates from birth to adulthood. Neuroimage 47, S102 (2009).

    Article  Google Scholar 

  • Fox, M. D. et al. Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases. Proc. Natl Acad. Sci. USA 111, E4367–E4375 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  • Yamamoto, K. et al. Neuromodulation for pain: a comprehensive survey and systematic review of clinical trials and connectomic analysis of brain targets. Stereotact. Funct. Neurosurg. 100, 14–25 (2022).

    Article  PubMed  Google Scholar 

  • Fox, M. D., Liu, H. & Pascual-Leone, A. Identification of reproducible individualized targets for treatment of depression with TMS based on intrinsic connectivity. Neuroimage 66, 151–160 (2013).

    Article  PubMed  Google Scholar 

  • Horn, A. et al. Lead-DBS v2: towards a comprehensive pipeline for deep brain stimulation imaging. Neuroimage 184, 293–316 (2019).

    Article  PubMed  Google Scholar 

  • Neudorfer, C. et al. Lead-DBS v3.0: mapping deep brain stimulation effects to local anatomy and global networks. Neuroimage 268, 119862 (2023).

  • Rubinov, M. & Sporns, O. Complex network measures of brain connectivity: uses and interpretations. Neuroimage 52, 1059–1069 (2010).

    Article  PubMed  Google Scholar 

  • Kwon, H., Choi, Y.-H. & Lee, J.-M. A Physarum centrality measure of the human brain network. Sci. Rep. 9, 5907 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  • Neudorfer, C. et al. A high-resolution in vivo magnetic resonance imaging atlas of the human hypothalamic region. Sci. Data 7, 305 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  • Christensen, D. D., Laitinen, L. V., Schmidt, L. J. & Hariz, M. I. Anterior capsulotomy for treatment of refractory obsessive-compulsive disorder: results in a young and an old patient. Stereotact. Funct. Neurosurg. 79, 234–244 (2003).

    Article  Google Scholar 

  • D’Astous, M., Cottin, S., Roy, M., Picard, C. & Cantin, L. Bilateral stereotactic anterior capsulotomy for obsessive-compulsive disorder: long-term follow-up. J. Neurol. Neurosurg. Psychiatry 84, 1208–1213 (2013).

    Article  PubMed  Google Scholar 

  • Liu, K. et al. Stereotactic treatment of refractory obsessive compulsive disorder by bilateral capsulotomy with 3 years follow-up. J. Clin. Neurosci. 15, 622–629 (2008).

    Article  PubMed  Google Scholar 

  • Oliver, B. et al. Bilateral anterior capsulotomy for refractory obsessive-compulsive disorders. Stereotact. Funct. Neurosurg. 81, 90–95 (2003).

    Article  PubMed  Google Scholar 

  • Rück, C. et al. Capsulotomy for obsessive-compulsive disorder: long-term follow-up of 25 patients. Arch. Gen. Psychiatry 65, 914–921 (2008).

    Article  PubMed  Google Scholar 

  • Zhan, S. et al. Long-term follow-up of bilateral anterior capsulotomy in patients with refractory obsessive-compulsive disorder. Clin. Neurol. Neurosurg. 119, 91–95 (2014).

    Article  PubMed  Google Scholar 

  • Zhang, C. et al. Effects of anterior capsulotomy on decision making in patients with refractory obsessive-compulsive disorder. Front. Psychol. 8, 1814 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  • Davidson, B. et al. Magnetic resonance-guided focused ultrasound capsulotomy for treatment-resistant psychiatric disorders. Oper. Neurosurg. 19, 741–749 (2020).

    Article  PubMed  Google Scholar 

  • Gong, F. et al. The suitability of different subtypes and dimensions of obsessive-compulsive disorder for treatment with anterior capsulotomy: a long-term follow-up study. Stereotact. Funct. Neurosurg. 97, 319–336 (2019).

    Article  PubMed  Google Scholar 

  • Chang, W. S., Roh, D., Kim, C.-H. & Chang, J. W. Combined bilateral anterior cingulotomy and ventral capsule/ventral striatum deep brain stimulation for refractory obsessive-compulsive disorder with major depression: do combined procedures have a long-term benefit? Restor. Neurol. Neurosci. 31, 723–732 (2013).

    PubMed  Google Scholar 

  • Sheth, S. A. et al. Limbic system surgery for treatment-refractory obsessive-compulsive disorder: a prospective long-term follow-up of 64 patients. J. Neurosurg. 118, 491–497 (2013).

    Article  PubMed  Google Scholar 

  • Zhang, Q. J., Wang, W. H. & Wei, X. P. Long-term efficacy of stereotactic bilateral anterior cingulotomy and bilateral anterior capsulotomy as a treatment for refractory obsessive-compulsive disorder. Stereotact. Funct. Neurosurg. 91, 258–261 (2013).

    Article  PubMed  Google Scholar 

  • Baer, L. et al. Cingulotomy for intractable obsessive-compulsive disorder. Prospective long-term follow-up of 18 patients. Arch. Gen. Psychiatry 52, 384–392 (1995).

    Article  PubMed  Google Scholar 

  • Csigó, K. et al. Long-term follow-up of patients with obsessive-compulsive disorder treated by anterior capsulotomy: a neuropsychological study. J. Affect. Disord. 126, 198–205 (2010).

    Article  PubMed  Google Scholar 

  • Sheehan, J. P., Patterson, G., Schlesinger, D. & Xu, Z. γ knife surgery anterior capsulotomy for severe and refractory obsessive-compulsive disorder. J. Neurosurg. 119, 1112–1118 (2013).

    Article  PubMed  Google Scholar 

  • Spatola, G. et al. Results of Gamma Knife anterior capsulotomy for refractory obsessive-compulsive disorder: results in a series of 10 consecutive patients. J. Neurosurg. 131, 376–383 (2018).

    Article  PubMed  Google Scholar 

  • Rasmussen, S. A. et al. Gamma ventral capsulotomy in intractable obsessive-compulsive disorder. Biol. Psychiatry 84, 355–364 (2018).

    Article  PubMed  Google Scholar 

  • Kim, S. J. et al. A study of novel bilateral thermal capsulotomy with focused ultrasound for treatment-refractory obsessive-compulsive disorder: 2-year follow-up. J. Psychiatry Neurosci. 43, 327–337 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  • Liu, H. B., Zhong, Q. & Wang, W. Bilateral anterior capsulotomy for patients with refractory obsessive-compulsive disorder: a multicenter, long-term, follow-up study. Neurol. India 65, 770–776 (2017).

    Article  PubMed  Google Scholar 

  • Lopes, A. C. et al. Treatment of resistant obsessive-compulsive disorder with ventral capsular/ventral striatal gamma capsulotomy: a pilot prospective study. J. Neuropsychiatry Clin. Neurosci. 21, 381–392 (2009).

    Article  PubMed  Google Scholar 

  • Kondziolka, D., Flickinger, J. C. & Hudak, R. Results following gamma knife radiosurgical anterior capsulotomies for obsessive compulsive disorder. Neurosurgery 68, 28–32 (2011).

    Article  PubMed  Google Scholar 

  • Lopes, A. C. et al. Gamma ventral capsulotomy for obsessive-compulsive disorder: a randomized clinical trial. JAMA Psychiatry 71, 1066–1076 (2014).

    Article  PubMed  Google Scholar 

  • Jung, H. H. et al. Bilateral anterior cingulotomy for refractory obsessive-compulsive disorder: long-term follow-up results. Stereotact. Funct. Neurosurg. 84, 184–189 (2006).

    Article  PubMed  Google Scholar 

  • Doshi, P. K. Radiofrequency lesioning for movement and psychiatric disorders-experience of 107 cases. Front. Hum. Neurosci. 15, 673848 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  • McLaughlin, N. C. R. et al. Magnetic resonance imaging-guided laser thermal ventral capsulotomy for intractable obsessive-compulsive disorder. Neurosurgery 88, 1128–1135 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  • Peker, S. et al. Efficacy and safety of gamma ventral capsulotomy for treatment-resistant obsessive-compulsive disorder: a single-center experience. World Neurosurg. 141, e941–e952 (2020).

    Article  PubMed  Google Scholar 

  • Satzer, D., Mahavadi, A., Lacy, M., Grant, J. E. & Warnke, P. Interstitial laser anterior capsulotomy for obsessive-compulsive disorder: lesion size and tractography correlate with outcome. J. Neurol. Neurosurg. Psychiatry 93, 317–323 (2022).

    Article  PubMed  Google Scholar 

  • Starkweather, C. K., Bick, S. K., McHugh, J. M., Dougherty, D. D. & Williams, Z. M. Lesion location and outcome following cingulotomy for obsessive-compulsive disorder. J. Neurosurg. 136, 221–230 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  • Chang, J. G. et al. Evaluation of changes in neural oscillation after bilateral capsulotomy in treatment refractory obsessive-compulsive disorder using magnetoencephalogram. Asian J. Psychiatr. 82, 103473 (2023).

    Article  PubMed  Google Scholar 

  • Hagy, H. A. et al. Increased apathy post-interstitial laser capsulotomy for refractory obsessive-compulsive disorder. J. Neurol. Neurosurg. Psychiatry 95, 899–901 (2024).

    PubMed  Google Scholar 

  • Abelson, J. L. et al. Deep brain stimulation for refractory obsessive-compulsive disorder. Biol. Psychiatry 57, 510–516 (2005).

    Article  PubMed  Google Scholar 

  • Barcia, J. A. et al. Deep brain stimulation for obsessive-compulsive disorder: is the side relevant? Stereotact. Funct. Neurosurg. 92, 31–36 (2014).

    Article  PubMed  Google Scholar 

  • Chabardès, S. et al. Deep brain stimulation for obsessive-compulsive disorder: subthalamic nucleus target. World Neurosurg. 80, S31.e1–8 (2013).

    Article  PubMed  Google Scholar 

  • Coenen, V. A. et al. The medial forebrain bundle as a target for deep brain stimulation for obsessive-compulsive disorder. CNS Spectr. 22, 282–289 (2017).

    Article  PubMed  Google Scholar 

  • Denys, D. et al. Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder. Arch. Gen. Psychiatry 67, 1061–1068 (2010).

    Article  PubMed  Google Scholar 

  • Fayad, S. M. et al. Six-nine year follow-up of deep brain stimulation for obsessive-compulsive disorder. PLoS One 11, e0167875 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  • Figee, M. et al. Deep brain stimulation induces striatal dopamine release in obsessive-compulsive disorder. Biol. Psychiatry 75, 647–652 (2014).

    Article  PubMed  Google Scholar 

  • Gabriëls, L., Cosyns, P., Nuttin, B., Demeulemeester, H. & Gybels, J. Deep brain stimulation for treatment-refractory obsessive-compulsive disorder: psychopathological and neuropsychological outcome in three cases. Acta Psychiatr. Scand. 107, 275–282 (2003).

    Article  PubMed  Google Scholar 

  • Goodman, W. K. et al. Deep brain stimulation for intractable obsessive compulsive disorder: pilot study using a blinded, staggered-onset design. Biol. Psychiatry 67, 535–542 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  • Huff, W. et al. Unilateral deep brain stimulation of the nucleus accumbens in patients with treatment-resistant obsessive-compulsive disorder: outcomes after one year. Clin. Neurol. Neurosurg. 112, 137–143 (2010).

    Article  PubMed  Google Scholar 

  • Maarouf, M. et al. Deep brain stimulation of medial dorsal and ventral anterior nucleus of the thalamus in OCD: a retrospective case series. PLoS ONE 11, e0160750 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  • Mallet, L. et al. Subthalamic nucleus stimulation in severe obsessive-compulsive disorder. N. Engl. J. Med. 359, 2121–2134 (2008).

    Article  PubMed  Google Scholar 

  • Roh, D., Chang, W. S., Chang, J. W. & Kim, C.-H. Long-term follow-up of deep brain stimulation for refractory obsessive-compulsive disorder. Psychiatry Res. 200, 1067–1070 (2012).

    Article  PubMed  Google Scholar 

  • Tsai, H.-C. et al. Pilot study of deep brain stimulation in refractory obsessive-compulsive disorder ethnic Chinese patients. Psychiatry Clin. Neurosci. 66, 303–312 (2012).

    Article  PubMed  Google Scholar 

  • van den Munckhof, P. et al. Active stimulation site of nucleus accumbens deep brain stimulation in obsessive-compulsive disorder is localized in the ventral internal capsule. Acta Neurochir. Suppl. 117, 53–59 (2013).

    Article  PubMed  Google Scholar 

  • Franzini, A. et al. Deep-brain stimulation of the nucleus accumbens in obsessive compulsive disorder: clinical, surgical and electrophysiological considerations in two consecutive patients. Neurol. Sci. 31, 353–359 (2010).

    Article  PubMed  Google Scholar 

  • Jiménez-Ponce, F. et al. Preliminary study in patients with obsessive-compulsive disorder treated with electrical stimulation in the inferior thalamic peduncle. Neurosurgery 65, 203–209 (2009).

    PubMed  Google Scholar 

  • Jiménez, F. et al. Electrical stimulation of the inferior thalamic peduncle in the treatment of major depression and obsessive compulsive disorders. World Neurosurg. 80, S30.e17–25 (2013).

    Article  PubMed  Google Scholar 

  • Greenberg, B. D. et al. Three-year outcomes in deep brain stimulation for highly resistant obsessive-compulsive disorder. Neuropsychopharmacology 31, 2384–2393 (2006).

    Article  PubMed  Google Scholar 

  • Nuttin, B. J. et al. Long-term electrical capsular stimulation in patients with obsessive-compulsive disorder. Neurosurgery 52, 1263–1272 (2003).

    Article  PubMed  Google Scholar 

  • Ooms, P. et al. Cost-effectiveness of deep brain stimulation versus treatment as usual for obsessive-compulsive disorder. Brain Stimul. 111, 836–842 (2017).

    Article  Google Scholar 

  • Denys, D. et al. Efficacy of deep brain stimulation of the ventral anterior limb of the internal capsule for refractory obsessive-compulsive disorder: a clinical cohort of 70 patients. Am. J. Psychiatry 177, 265–271 (2020).

    Article  PubMed  Google Scholar 

  • Menchón, J. M. et al. A prospective international multi-center study on safety and efficacy of deep brain stimulation for resistant obsessive-compulsive disorder. Mol. Psychiatry 26, 1234–1247 (2021).

    Article  PubMed  Google Scholar 

  • Luyten, L., Hendrickx, S., Raymaekers, S., Gabriëls, L. & Nuttin, B. Electrical stimulation in the bed nucleus of the stria terminalis alleviates severe obsessive-compulsive disorder. Mol. Psychiatry 21, 1272–1280 (2016).

    Article  PubMed  Google Scholar 

  • Guehl, D. et al. Neuronal correlates of obsessions in the caudate nucleus. Biol. Psychiatry 63, 557–562 (2008).

    Article  PubMed  Google Scholar 

  • Servello, D. et al. De novo and rescue DBS leads for refractory Tourette syndrome patients with severe comorbid OCD: a multiple case report. J. Neurol. 256, 1533–1539 (2009).

    Article  PubMed  Google Scholar 

  • Haq, I. U. et al. Smile and laughter induction and intraoperative predictors of response to deep brain stimulation for obsessive-compulsive disorder. Neuroimage 54, S247–S255 (2011).

    Article  PubMed  Google Scholar 

  • Hartmann, C. J. et al. Tractography activation patterns in dorsolateral prefrontal cortex suggest better clinical responses in OCD DBS. Front. Neurosci. 9, 519 (2015).

    PubMed  Google Scholar 

  • Lee, D. J. et al. Inferior thalamic peduncle deep brain stimulation for treatment-refractory obsessive-compulsive disorder: a phase 1 pilot trial. Brain Stimul. 12, 344–352 (2019).

    Article  PubMed  Google Scholar 

  • Kohl, S. et al. Effects of deep brain stimulation on prepulse inhibition in obsessive-compulsive disorder. Transl. Psychiatry 5, e675 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  • Polak, A. R. et al. Deep brain stimulation for obsessive-compulsive disorder affects language: a case report. Neurosurgery 73, E907–10 (2013).

    Article  PubMed  Google Scholar 

  • Huys, D. et al. Open-label trial of anterior limb of internal capsule-nucleus accumbens deep brain stimulation for obsessive-compulsive disorder: insights gained. J. Neurol. Neurosurg. Psychiatry 90, 805–812 (2019).

    Article  PubMed  Google Scholar 

  • Farrand, S. et al. Deep brain stimulation for severe treatment-resistant obsessive-compulsive disorder: an open-label case series. Aust. N. Z. J. Psychiatry 52, 699–708 (2018).

    Article  PubMed  Google Scholar 

  • Islam, L., Franzini, A., Messina, G., Scarone, S. & Gambini, O. Deep brain stimulation of the nucleus accumbens and bed nucleus of stria terminalis for obsessive-compulsive disorder: a case series. World Neurosurg. 83, 657–663 (2015).

    Article  PubMed  Google Scholar 

  • Mallet, L. et al. Compulsions, Parkinson’s disease, and stimulation. Lancet 360, 1302–1304 (2002).

    Article  PubMed  Google Scholar 

  • Mallet, L. et al. Long-term effects of subthalamic stimulation in obsessive-compulsive disorder: follow-up of a randomized controlled trial. Brain Stimul. 12, 1080–1082 (2019).

    Article  PubMed  Google Scholar 

  • Holland, M. T. et al. Deep brain stimulation for obsessive-compulsive disorder: a long term naturalistic follow up study in a single institution. Front. Psychiatry 11, 55 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  • Tyagi, H. et al. A randomized trial directly comparing ventral capsule and anteromedial subthalamic nucleus stimulation in obsessive-compulsive disorder: clinical and imaging evidence for dissociable effects. Biol. Psychiatry 85, 726–734 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  • Barcia, J. A. et al. Personalized striatal targets for deep brain stimulation in obsessive-compulsive disorder. Brain Stimul. 12, 724–734 (2019).

    Article  PubMed  Google Scholar 

  • Chabardes, S. et al. Deep brain stimulation of the subthalamic nucleus in obsessive-compulsives disorders: long-term follow-up of an open, prospective, observational cohort. J. Neurol. Neurosurg. Psychiatry 91, 1349–1356 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  • Graat, I. et al. Is deep brain stimulation effective and safe for patients with obsessive compulsive disorder and comorbid bipolar disorder? J. Affect. Disord. 264, 69–75 (2020).

    Article  PubMed  Google Scholar 

  • Graat, I. et al. Effectiveness and safety of deep brain stimulation for patients with refractory obsessive compulsive disorder and comorbid autism spectrum disorder; a case series. J. Affect. Disord. 299, 492–497 (2022).

    Article  PubMed  Google Scholar 

  • Jiang, F. et al. Patient-specific modeling of the volume of tissue activated (VTA) is associated with clinical outcome of DBS in patients with an obsessive-compulsive disorder. In 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) 5889–5892 (IEEE, 2021).

  • Mosley, P. E. et al. A randomised, double-blind, sham-controlled trial of deep brain stimulation of the bed nucleus of the stria terminalis for treatment-resistant obsessive-compulsive disorder. Transl. Psychiatry 11, 190 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  • Naesström, M., Hariz, M., Strömsten, L., Bodlund, O. & Blomstedt, P. Deep brain stimulation in the bed nucleus of stria terminalis in obsessive-compulsive disorder-1-year follow-up. World Neurosurg. 149, e794–e802 (2021).

    Article  PubMed  Google Scholar 

  • Torres Díaz, C. V. et al. Deep brain stimulation of the nucleus accumbens, ventral striatum, or internal capsule targets for medication-resistant obsessive-compulsive disorder: a multicenter study. World Neurosurg. 155, e168–e176 (2021).

    Article  PubMed  Google Scholar 

  • Welter, M.-L. et al. Deep brain stimulation of the subthalamic, accumbens, or caudate nuclei for patients with severe obsessive-compulsive disorder: a randomized crossover controlled study. Biol. Psychiatry. 90, e45–e47 (2021).

    Article  PubMed  Google Scholar 

  • Graat, I. et al. Cyclic versus continuous deep brain stimulation in patients with obsessive compulsive disorder: a randomized controlled trial. Brain Stimul. 16, 82–87 (2023).

    Article  PubMed  Google Scholar 

  • Luyck, K., Bervoets, C., Deblieck, C., Nuttin, B. & Luyten, L. Deep brain stimulation in the bed nucleus of the stria terminalis: a symptom provocation study in patients with obsessive-compulsive disorder. J. Psychiatr. Res. 151, 252–260 (2022).

    Article  PubMed  Google Scholar 

  • Acevedo, N. et al. Clinical outcomes of deep brain stimulation for obsessive-compulsive disorder: insight as a predictor of symptom changes. Psychiatry Clin. Neurosci. 78, 131–141 (2024).

    Article  PubMed  Google Scholar 

  • Allam, A. K. et al. Effective deep brain stimulation for obsessive-compulsive disorder after failed anterior capsulotomy: illustrative cases. J. Neurosurg. Case Lessons 8, CASE24289 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  • Knebel, J., McClure, R. K. & Kennedy, M. L. H. Assessing the pharmacotherapy and clinical outcomes after deep brain stimulation for treatment-refractory obsessive-compulsive disorder: a case-cohort study. J. Clin. Med. 13, 6549 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  • Mar-Barrutia, L. et al. Long-term comparative effectiveness of deep brain stimulation in severe obsessive-compulsive disorder. Brain Stimul. 15, 1128–1138 (2022).

    Article  PubMed  Google Scholar 

  • Provenza, N. R. et al. Disruption of neural periodicity predicts clinical response after deep brain stimulation for obsessive-compulsive disorder. Nat. Med. 30, 3004–3014 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  • Wan, X. et al. Telemedicine in patients with obsessive-compulsive disorder after deep brain stimulation: a case series. Front. Hum. Neurosci. 18, 1296726 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  • Alonso, P. et al. Right prefrontal repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: a double-blind, placebo-controlled study. Am J. Psychiatry 158, 1143–1145 (2001).

    Article  PubMed  Google Scholar 

  • Arumugham, S. S. et al. Augmentation effect of low-frequency repetitive transcranial magnetic stimulation over presupplementary motor area in obsessive-compulsive disorder: a randomized controlled trial. J. ECT 34, 253–257 (2018).

    Article  PubMed  Google Scholar 

  • Badawy, A. A., El Sawy, H. & Abd El Hay, M. Efficacy of repetitive transcranial magnetic stimulation in the management of obsessive compulsive disorder. Egypt J. Neurol. Psychiatry Neurosurg 47, 393–398 (2010).

    Google Scholar 

  • Donse, L., Sack, A. T., Fitzgerald, P. B. & Arns, M. Sleep disturbances in obsessive-compulsive disorder: association with non-response to repetitive transcranial magnetic stimulation (rTMS). Brain Stimul. 10, 384 (2017).

    Article  Google Scholar 

  • Dunlop, K. et al. Reductions in cortico-striatal hyperconnectivity accompany successful treatment of obsessive-compulsive disorder with dorsomedial prefrontal rTMS. Neuropsychopharmacology 41, 1395–1403 (2016).

    Article  PubMed  Google Scholar 

  • Elbeh, K. A. M. et al. Repetitive transcranial magnetic stimulation in the treatment of obsessive-compulsive disorders: double blind randomized clinical trial. Psychiatry Res. 238, 264–269 (2016).

    Article  PubMed  Google Scholar 

  • Gomes, P. V. O., Brasil-Neto, J. P., Allam, N. & Rodrigues de Souza, E. A randomized, double-blind trial of repetitive transcranial magnetic stimulation in obsessive-compulsive disorder with three-month follow-up. J. Neuropsychiatry Clin. Neurosci. 24, 437–443 (2012).

    Article  PubMed  Google Scholar 

  • Haghighi, M. et al. Repetitive transcranial magnetic stimulation (rTMS) improves symptoms and reduces clinical illness in patients suffering from OCD—results from a single-blind, randomized clinical trial with sham cross-over condition. J. Psychiatr. Res. 68, 238–244 (2015).

    Article  PubMed  Google Scholar 

  • Harika-Germaneau, G. et al. Continuous theta burst stimulation over the supplementary motor area in refractory obsessive-compulsive disorder treatment: a randomized sham-controlled trial. Brain Stimul. 12, 1565–1571 (2019).

    Article  PubMed  Google Scholar 

  • Hawken, E. R. et al. Transcranial magnetic stimulation of the supplementary motor area in the treatment of obsessive-compulsive disorder: a multi-site study. Int. J. Mol. Sci. 17, 420 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  • Jahanbakhsh, G., Alireza Haji Seyed Javadi, S., Majidi, M., Khademi, M. & Karimi, R. Effectiveness of adjunctive low-frequency repetitive transcranial magnetic stimulation therapy over the left dorsolateral prefrontal cortex in patients with obsessive-compulsive disorder refractory to medical treatment: a double-blind, randomized clinical trial. Asian J. Psychiatr. 80, 103384 (2023).

    Article  PubMed  Google Scholar 

  • Ji, G.-J. et al. Pre-supplementary motor network connectivity and clinical outcome of magnetic stimulation in obsessive-compulsive disorder. Hum. Brain Mapp. 42, 3833–3844 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  • Jiang, J. et al. A controlled clinical study of accelerated high-dose theta burst stimulation in patients with obsessive-compulsive disorder. Neural Plast. 2023, 2741287 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  • Kang, J. I., Kim, C.-H., Namkoong, K., Lee, C.-I. & Kim, S. J. A randomized controlled study of sequentially applied repetitive transcranial magnetic stimulation in obsessive-compulsive disorder. J. Clin. Psychiatry 70, 1645–1651 (2009).

    Article  PubMed  Google Scholar 

  • Khedr, E. M., Elbeh, K., Saber, M., Abdelrady, Z. & Abdelwarith, A. A double blind randomized clinical trial of the effectiveness of low frequency rTMS over right DLPFC or OFC for treatment of obsessive-compulsive disorder. J. Psychiatr. Res. 156, 122–131 (2022).

    Article  PubMed  Google Scholar 

  • Kumar, N. & Chadda, R. K. Augmentation effect of repetitive transcranial magnetic stimulation over the supplementary motor cortex in treatment refractory patients with obsessive compulsive disorder. Indian J. Psychiatry 53, 340–342 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  • Kumar, S., Singh, S., Chadda, R. K., Verma, R. & Kumar, N. The effect of low-frequency repetitive transcranial magnetic stimulation at orbitofrontal cortex in the treatment of patients with medication-refractory obsessive-compulsive disorder: a retrospective open study. J. ECT 34, e16–e19 (2018).

    Article  PubMed  Google Scholar 

  • Lee, Y.-J. et al. Repetitive transcranial magnetic stimulation of the supplementary motor area in treatment-resistant obsessive-compulsive disorder: an open-label pilot study. J. Clin. Neurosci. 44, 264–268 (2017).

    Article  PubMed  Google Scholar 

  • Luo, G. et al. Direct changes of neurometabolic concentrations in the pregenual anterior cingulate cortex among obsessive-compulsive patients after repetitive transcranial magnetic stimulation treatment. J. Affect. Disord. 333, 79–85 (2023).

    Article  PubMed  Google Scholar 

  • Ma, X., Huang, Y., Liao, L. & Jin, Y. A randomized double-blinded sham-controlled trial of α electroencephalogram-guided transcranial magnetic stimulation for obsessive-compulsive disorder. Chin. Med. J. (Engl.) 127, 601–606 (2014).

    Article  PubMed  Google Scholar 

  • Mansur, C. G. et al. Placebo effect after prefrontal magnetic stimulation in the treatment of resistant obsessive-compulsive disorder: a randomized controlled trial. Int. J. Neuropsychopharmacol. 14, 1389–1397 (2011).

    Article  PubMed  Google Scholar 

  • Mantovani, A. et al. Repetitive transcranial magnetic stimulation (rTMS) in the treatment of obsessive-compulsive disorder (OCD) and Tourette’s syndrome (TS). Int. J. Neuropsychopharmacol. 9, 95–100 (2006).

    Article  PubMed  Google Scholar 

  • Mantovani, A., Westin, G., Hirsch, J. & Lisanby, S. H. Functional magnetic resonance imaging guided transcranial magnetic stimulation in obsessive-compulsive disorder. Biol. Psychiatry 67, e39–40 (2010).

    Article  PubMed  Google Scholar 

  • Mantovani, A., Simpson, H. B., Fallon, B. A., Rossi, S. & Lisanby, S. H. Randomized sham-controlled trial of repetitive transcranial magnetic stimulation in treatment-resistant obsessive-compulsive disorder. Int. J. Neuropsychopharmacol. 13, 217–227 (2010).

    Article  PubMed  Google Scholar 

  • Mantovani, A. et al. Functional connectivity changes and symptoms improvement after personalized, double-daily dosing, repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: a pilot study. J. Psychiatr. Res. 136, 560–570 (2021).

    Article  PubMed  Google Scholar 

  • Modirrousta, M. et al. The efficacy of deep repetitive transcranial magnetic stimulation over the medial prefrontal cortex in obsessive compulsive disorder: results from an open-label study. Depress. Anxiety 32, 445–450 (2015).

    Article  PubMed  Google Scholar 

  • Mudunuru, A. K. et al. The clinical efficacy of accelerated deep repetitive transcranial magnetic stimulation in depression and obsessive-compulsive disorder: multi-centric real-world observational data. Cureus 16, e60895 (2024).

    PubMed  PubMed Central  Google Scholar 

  • Nauczyciel, C. et al. Repetitive transcranial magnetic stimulation over the orbitofrontal cortex for obsessive-compulsive disorder: a double-blind, crossover study. Transl. Psychiatry 4, e436 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  • Ozer, U., Yucens, B. & Tumkaya, S. Efficacy of accelerated deep transcranial magnetic stimulation wi̇th double cone coi̇l in obsessive-compulsive disorder: a double-blind, placebo-controlled study. J. Psychiatr. Res. 171, 325–331 (2024).

    Article  PubMed  Google Scholar 

  • Pallanti, S., Marras, A., Salerno, L., Makris, N. & Hollander, E. Better than treated as usual: transcranial magnetic stimulation augmentation in selective serotonin reuptake inhibitor-refractory obsessive-compulsive disorder, mini-review and pilot open-label trial. J. Psychopharmacol. 30, 568–578 (2016).

    Article  PubMed  Google Scholar 

  • Pelissolo, A. et al. Repetitive transcranial magnetic stimulation to supplementary motor area in refractory obsessive-compulsive disorder treatment: a sham-controlled trial. Int. J. Neuropsychopharmacol. 19, pyw025 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  • Prasko, J. et al. The effect of repetitive transcranial magnetic stimulation (rTMS) on symptoms in obsessive compulsive disorder. A randomized, double blind, sham controlled study. Neuro. Endocrinol. Lett. 27, 327–332 (2006).

    PubMed  Google Scholar 

  • Ruffini, C. et al. Augmentation effect of repetitive transcranial magnetic stimulation over the orbitofrontal cortex in drug-resistant obsessive-compulsive disorder patients: a controlled investigation. Prim. Care Companion J. Clin. Psychiatry 11, 226–230 (2009).

    PubMed  PubMed Central  Google Scholar 

  • Sachdev, P. S. et al. Right versus left prefrontal transcranial magnetic stimulation for obsessive-compulsive disorder: a preliminary investigation. J. Clin. Psychiatry 62, 981–984 (2001).

    Article  PubMed  Google Scholar 

  • Sachdev, P. S., Loo, C. K., Mitchell, P. B., McFarquhar, T. F. & Malhi, G. S. Repetitive transcranial magnetic stimulation for the treatment of obsessive compulsive disorder: a double-blind controlled investigation. Psychol. Med. 37, 1645–1649 (2007).

    Article  PubMed  Google Scholar 

  • Sarkhel, S., Sinha, V. K. & Praharaj, S. K. Adjunctive high-frequency right prefrontal repetitive transcranial magnetic stimulation (rTMS) was not effective in obsessive-compulsive disorder but improved secondary depression. J. Anxiety Disord. 24, 535–539 (2010).

    Article  PubMed  Google Scholar 

  • Seo, H.-J. et al. Adjunctive low-frequency repetitive transcranial magnetic stimulation over the right dorsolateral prefrontal cortex in patients with treatment-resistant obsessive-compulsive disorder: a randomized controlled trial. Clin. Psychopharmacol. Neurosci. 14, 153–160 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  • Singh, S., Kumar, S., Gupta, A., Verma, R. & Kumar, N. Effectiveness and predictors of response to 1-Hz repetitive transcranial magnetic stimulation in patients with obsessive-compulsive disorder. J. ECT 35, 61–66 (2019).

    Article  PubMed  Google Scholar 

  • Tadayonnejad, R. et al. Sequential multi-locus transcranial magnetic stimulation for treatment of obsessive-compulsive disorder with comorbid major depression: a case series. Brain Stimul. 13, 1600–1602 (2020).

    Article  PubMed  Google Scholar 

  • Tadayonnejad, R. et al. Safety and efficacy of targeting the supplementary motor area with double-cone deep transcranial magnetic stimulation vs figure-eight coil in treatment of obsessive-compulsive disorder with comorbid major depressive disorder. J. Psychiatr. Res. 179, 295–299 (2024).

    Article  PubMed  Google Scholar 

  • Vidya, K. L., Rao, P. G. & Goyal, N. Adjuvant priming repetitive transcranial magnetic stimulation for treatment-resistant obsessive-compulsive disorder: in search of a new paradigm! J. ECT 38, e1–e8 (2022).

    Article  PubMed  Google Scholar 

  • Ikawa, H., Osawa, R., Sato, A., Mizuno, H. & Noda, Y. A case series of deep transcranial magnetic stimulation treatment for patients with obsessive-compulsive disorder in the Tokyo metropolitan area. J. Clin. Med. 11, 6133 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  • Akbari, S., Hassani-Abharian, P. & Tajeri, B. The effect of transcranial direct current stimulation (tDCS) on cerebellum in reduction of the symptoms of obsessive-compulsive disorder. Neurocase 28, 135–139 (2022).

    Article  PubMed  Google Scholar 

  • Alizadehgoradel, J. et al. Targeting the prefrontal-supplementary motor network in obsessive-compulsive disorder with intensified electrical stimulation in two dosages: a randomized, controlled trial. Transl. Psychiatry 14, 78 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  • Bation, R., Poulet, E., Haesebaert, F., Saoud, M. & Brunelin, J. Transcranial direct current stimulation in treatment-resistant obsessive-compulsive disorder: an open-label pilot study. Prog. Neuropsychopharmacol. Biol. Psychiatry 65, 153–157 (2016).

    Article  PubMed  Google Scholar 

  • Bation, R., Mondino, M., Le Camus, F., Saoud, M. & Brunelin, J. Transcranial direct current stimulation in patients with obsessive compulsive disorder: a randomized controlled trial. Eur. Psychiatry 62, 38–44 (2019).

    Article  PubMed  Google Scholar 

  • Cheng, J. et al. Transcranial direct current stimulation improve symptoms and modulates cortical inhibition in obsessive-compulsive disorder: a TMS-EEG study. J. Affect. Disord. 298, 558–564 (2022).

    Article  PubMed  Google Scholar 

  • D’Urso, G. et al. Transcranial direct current stimulation for obsessive-compulsive disorder: a randomized, controlled, partial crossover trial. Depress. Anxiety 33, 1132–1140 (2016).

    Article  PubMed  Google Scholar 

  • Fineberg, N. A. et al. Feasibility, acceptability and practicality of transcranial stimulation in obsessive compulsive symptoms (FEATSOCS): a randomised controlled crossover trial. Compr. Psychiatry 122, 152371 (2023).

    Article  PubMed  Google Scholar 

  • Gowda, S. M. et al. Efficacy of pre-supplementary motor area transcranial direct current stimulation for treatment resistant obsessive compulsive disorder: a randomized, double blinded, sham controlled trial. Brain Stimul. 12, 922–929 (2019).

    Article  PubMed  Google Scholar 

  • Klimke, A., Nitsche, M. A., Maurer, K. & Voss, U. Case report: successful treatment of therapy-resistant OCD with application of transcranial alternating current stimulation (tACS). Brain Stimul. 9, 463–465 (2016).

    Article  PubMed  Google Scholar 

  • Kumar, S., Kumar, N. & Verma, R. Safety and efficacy of adjunctive transcranial direct current stimulation in treatment-resistant obsessive-compulsive disorder: an open-label trial. Indian J. Psychiatry 61, 327–334 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  • Najafi, K. et al. Efficacy of transcranial direct current stimulation in the treatment: resistant patients who suffer from severe obsessive-compulsive disorder. Indian J. Psychol. Med. 39, 573–578 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  • Narayanaswamy, J. C. et al. Successful application of add-on transcranial direct current stimulation (tDCS) for treatment of SSRI resistant OCD. Brain Stimul. 8, 655–657 (2015).

    Article  PubMed  Google Scholar 

  • Silva, R. D. M. F. D., Brunoni, A. R., Miguel, E. C. & Shavitt, R. G. Transcranial direct current stimulation for treatment-resistant obsessive-compulsive disorder: report on two cases and proposal for a randomized, sham-controlled trial. Sao Paulo Med. J. 134, 446–450 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

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