Why pain matters in treatment-resistant depression – Nature Mental Health

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Chronic pain often coincides with treatment-resistant depression, and can be a major contributor to antidepressant failure, but is seldom taken into account. In this Comment, we suggest ways of incorporating pain measurement and management into the care of people with this form of depression.

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Authors and Affiliations

  1. Clinical Investigation, Harvard Medical School, Boston, MA, USA

    Nilson N. Mendes Neto

  2. Pain Psychiatry Fellowship, NeuroPsy, Boston, MA, USA

    Nilson N. Mendes Neto & Jessika M. Mendes

  3. Pain Teaching Clinic, Universidade Potiguar, Natal, Brazil

    Nilson N. Mendes Neto

  4. Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King’s College, London, UK

    Brendon Stubbs

  5. Center for Sport Science and University Sports, University of Vienna, Vienna, Austria

    Brendon Stubbs

Authors

  1. Nilson N. Mendes Neto
  2. Jessika M. Mendes
  3. Brendon Stubbs

Corresponding author

Correspondence to Nilson N. Mendes Neto.

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Competing interests

The authors declare no competing interests.

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N. Mendes Neto, N., Mendes, J.M. & Stubbs, B. Why pain matters in treatment-resistant depression. Nat. Mental Health (2026). https://doi.org/10.1038/s44220-026-00691-9

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  • DOI: https://doi.org/10.1038/s44220-026-00691-9

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