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Chronic pain often coincides with treatment-resistant depression, and can be a major contributor to antidepressant failure, but is seldom taken into account. In this Comment, we suggest ways of incorporating pain measurement and management into the care of people with this form of depression.
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References
-
Stubbs, B. et al. Eur. Psychiat. 68, e113 (2025).
-
Kroenke, K. et al. J. Pain 12, 964–973 (2011).
-
Bair, M. J., Robinson, R. L., Katon, W. & Kroenke, K. Arch. Intern. Med. 163, 2433–2445 (2003).
-
Roughan, W. H. et al. Front. Psychiat. 12, 643609 (2021).
-
Fava, M., Mallinckrodt, C. H., Detke, M. J., Watkin, J. G. & Wohlreich, M. M. J. Clin. Psychiat. 65, 521–530 (2004).
-
Baliki, M. N. & Apkarian, A. V. Neuron 87, 474–491 (2015).
-
Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR) (American Psychiatric Association, 2022).
-
Levis, B. et al. JAMA 323, 191–202 (2020).
-
Kohler-Forsberg, O. et al. JAMA Psychiat. 80, 1196 (2023).
-
Booker, S. Q. & Herr, K. A. Am. J. Public Health 105, 2162–2168 (2015).
-
Mendes, N. N., Zacakim, M. & Mendes, J. M. Lancet Psychiat. 12, 728–730 (2025).
-
Mendes, N. N., Mendes, J. M., Duarte, T. & Stubbs, B. Lancet Healthy Longev. 6, 100787 (2025).
-
Dworkin, R. H. et al. Pain 113, 9–19 (2005).
-
Fekadu, A., Donocik, J. G. & Cleare, A. J. BMC Med. 16, 224 (2018).
-
McIntyre, R. S. et al. World Psychiat. 22, 394–412 (2023).
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N. Mendes Neto, N., Mendes, J.M. & Stubbs, B. Why pain matters in treatment-resistant depression. Nat. Mental Health (2026). https://doi.org/10.1038/s44220-026-00691-9
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DOI: https://doi.org/10.1038/s44220-026-00691-9
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