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Nature Mental Health volume 4, pages 694–695 (2026) Cite this article
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This study presents a multimodal, systems-level map of the human brain histamine system, integrating transcriptomics, molecular imaging, developmental trajectories and cognitive meta-analysis. The findings link histaminergic system architecture to higher-order cognition and vulnerability to major psychiatric disorders.
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References
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Schwartz, J. C. et al. Histaminergic transmission in the mammalian brain. Physiol. Rev. 71, 1–51 (1991). A seminal overview of histaminergic transmission in the mammalian brain.
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Haas, H. L. & Panula, P. The role of histamine and the tuberomamillary nucleus in the nervous system. Nat. Rev. Neurosci. 4, 121–130 (2003). This review discusses the tuberomammillary nucleus (the source of histaminergic neurons) and the role of histamine in arousal, cognition and homeostatic regulation.
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Panula, P. & Nuutinen, S. The histaminergic network in the brain: basic organization and role in disease. Nat. Rev. Neurosci. 14, 472–487 (2013). This review integrates anatomical, molecular and clinical evidence to map the organization of the histaminergic network and its involvement in brain disorders.
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This is a summary of: Martins, D. et al. Mapping histamine pathway networks in the human brain across cognition and psychiatric disorders. Nat. Mental Health https://doi.org/10.1038/s44220-026-00637-1 (2026).
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Mapping the human brain histamine system at the molecular, structural and functional levels. Nat. Mental Health 4, 694–695 (2026). https://doi.org/10.1038/s44220-026-00641-5
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DOI: https://doi.org/10.1038/s44220-026-00641-5

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