Reply to: A missed opportunity to examine reliability in computational psychiatry – Nature Mental Health

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replying to V. M. Brown. Nature Mental Health https://doi.org/10.1038/s44220-026-00662-0 (2025)

In our recent paper analyzing the relationship between personality, mental health measures, behavioral variables and modeling parameters, we made a general, cautionary claim regarding the current utility of computational metrics in clinical settings1. We certainly welcome discussions about how to improve the reliability of experimental practices but nonetheless highlight the necessity for fair evaluations of our tools and measures, in particular regarding their most clinically relevant properties.

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Author information

Authors and Affiliations

  1. PjSE CNRS UMR 8545, Paris, France

    Maël Lebreton

  2. Paris School of Economics, Paris, France

    Maël Lebreton

  3. Swiss Centre for Affective Science and Faculty of Psychology, University of Geneva, Geneva, Switzerland

    Maël Lebreton

  4. Departement d’Etudes Cognitives, Ecole Normale Supérieure, PSL Research University, Paris, France

    Stefano Vrizzi, Anis Najar & Stefano Palminteri

  5. Laboratoire de Neurosciences Cognitives et Computationnelles, Institut National de la Santé et Recherche Médicale, Paris, France

    Stefano Vrizzi, Anis Najar & Stefano Palminteri

  6. Center for Research in Epidemiology and StatisticS (CRESS), Université Paris Cité and Université Sorbonne Paris Nord, Paris, France

    Cédric Lemogne

  7. Service de Psychiatrie de l’Adulte, AP-HP, Hôpital Hôtel-Dieu, Paris, France

    Cédric Lemogne

Authors

  1. Maël Lebreton
  2. Stefano Vrizzi
  3. Anis Najar
  4. Cédric Lemogne
  5. Stefano Palminteri

Contributions

M.L. and S.P. conceptualized and drafted the response. S.V. and C.L. contributed key elements and supporting material. M.L., S.P., S.V., C.L. and A.N. reviewed and edited the paper.

Corresponding authors

Correspondence to Maël Lebreton or Stefano Palminteri.

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The authors declare no competing interests.

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Lebreton, M., Vrizzi, S., Najar, A. et al. Reply to: A missed opportunity to examine reliability in computational psychiatry. Nat. Mental Health (2026). https://doi.org/10.1038/s44220-026-00663-z

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