polygenic risk score
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anhedonia, bipolar disorder, Brain, endophenotype, fMRI, monetary incentive delay task, negative symptoms, neuroscience, polygenic risk score, Psychiatry, psychosis, reward processing, schizophrenia, ventral striatumReward Activation Failed as Bipolar-Psychosis Endophenotype
A 244-person functional MRI study found no significant evidence that ventral striatum…
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clinical staging, depression, early mental illness, genetics, gray matter volume, neuroscience, polygenic risk score, PRONIA, psychiatric biomarkers, Psychiatry, Psychology, psychosis risk, recent-onset depression, recent-onset psychosis, schizophrenia, transdiagnostic severityEarly Mental Illness Severity Tracks Genetics and Brain Volume in PRONIA
A 2026 PRONIA preprint involving 727 discovery-sample participants found that early mental…
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aMT6s, Brain, circadian rhythm, genetics, genome-wide association study, Hormones, melatonin, MTNR1B, multi-ancestry GWAS, polygenic risk score, sleep, sleep duration, type 2 diabetes, urinary biomarkerMelatonin aMT6s GWAS Found No Hits, PRS Linked to Sleep and Diabetes
A 2026 multi-ancestry genome-wide association study of urinary aMT6s, a melatonin metabolite…
