Brain
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AIP4, Alzheimer’s disease, amyloid beta, APP PS1 mice, Brain, cell cycle re-entry, clomipramine, drug repurposing, Drugs, Itch, memory, Neurodegenerative Diseases, neuronal apoptosisClomipramine Improved Alzheimer’s Mouse Memory by Blocking Itch in 45 Days
A 2026 iScience study found that 45 days of clomipramine improved spatial,…
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Brain, cognition, distraction, frontoparietal cortex, neuroscience, oblique effect, occipital cortex, orientation bias, posterior parietal cortex, sensory recruitment, tdcs, visual working memorytDCS Failed Visual Working Memory as Distraction Increased Orientation Bias
A 2026 two-experiment study found no visual-working-memory benefit from parietal or occipital…
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Brain, closed-loop stimulation, deep brain stimulation, drug-resistant epilepsy, epilepsy, intersectional short-pulse stimulation, ISP stimulation, medRxiv preprint, Neurostimulation, responsive neurostimulation, RNS, seizure duration, seizure incidence, subgaleal stimulation, therapy, therapy-resistant epilepsy, vagus nerve stimulationClosed-Loop Subgaleal ISP Reduced Epilepsy Seizure Incidence 80%
A 2026 first-in-human medRxiv preprint reported that closed-loop subgaleal intersectional short-pulse stimulation…
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AD/ADRD, Alzheimer’s disease, APOE-e4, Brain, cardiovascular risk, cognitive decline, Dementia, Drugs, Kaiser Permanente, LDL cholesterol, Neurodegenerative Diseases, observational bias, statins, target trial emulationStatins and Dementia Risk: No Long-Term Signal in 322,358 Patients
Statins do not look like a dementia-prevention drug, but they do not…
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Brain, cognitive remediation, depression, gamma neuromodulation, GENUS, iTBS, major depressive disorder, meta-analysis, Neurostimulation, schizophrenia, tACS, therapy, theta-burst stimulation, TMS, Tsai labGamma Brain Stimulation Helps Schizophrenia More Than Depression
A 2026 meta-analysis of 56 controlled trials found the clearest gamma-frequency neuromodulation…
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amygdala, Anxiety, anxiety disorders, associative learning, Brain, cognition, D-cycloserine, diffusion mri, exposure therapy, fear extinction, fMRI, hippocampus, prefrontal cortex, PTSD, therapyResting Brain Connectivity Predicts Fear Extinction Learning
A 2026 multimodal MRI analysis of 509 healthy adults found that fear…
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basal ganglia, Brain, deep brain stimulation, iTBS, MDS-UPDRS, Neurodegenerative Diseases, Neuromodulation, neuroscience, Neurostimulation, non invasive brain stimulation, parkinson’s disease, putamen, temporal interference stimulation, tTISTranscranial Temporal Interference Stimulation (tTIS) May Improve Parkinson’s Motor Symptoms
Deep brain stimulation works for Parkinson’s, but it requires implanted electrodes. A…
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alpha-synuclein, ambroxol, biomarker, Brain, exenatide, exercise, GLP-1 agonist, Neurodegenerative Diseases, parkinson’s disease, Prevention, prodromal, Psychology, RBD, REM sleep behavior disorder, sleepParkinson’s Disease Prevention: Prodromal Symptoms, RBD, Early Intervention Trials
Parkinson’s disease has a years-to-decades prodromal stage where motor symptoms haven’t yet…
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ADNI, Alzheimer’s disease, amyloid, APOE, APOE-e4, blood biomarker, Brain, cognition, donanemab, Drugs, genetics, lecanemab, longitudinal cohort, mild cognitive impairment, Neurodegenerative Diseases, neuroscience, p-tau217, preclinical ADPlasma p-tau217 Blood Test Predicts Alzheimer’s Risk 1.5x Stronger in APOE-e4
Until recently, Alzheimer’s pathology could only be confirmed in living patients via…
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anhedonia, antidepressants, Brain, cross-over RCT, depression, dopamine, locus coeruleus, major depressive disorder, motivation, neuroscience, Neurostimulation, Neurotransmitters, Psychiatry, reward-effort, treatment-resistant depression, tVNS, vagus nerve stimulationtVNS Alters Effort and Reward Decisions in Severe Depression
An ear-clip that modulates mood by stimulating the vagus nerve has obvious…
