Neurodegenerative Diseases
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autophagy, genetics, lysosomes, mitochondria, mitophagy, Neurodegenerative Diseases, neuroscience, Parkin, parkinson’s disease, PINK1, ubiquitinPINK1 and Parkin Link Parkinson’s Disease to Failed Mitochondrial Cleanup
A 2026 review ties the Parkinson’s disease genes PINK1 and parkin to…
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anti-CD20 therapy, Brain, cladribine, Delphi consensus, disease modifying therapy, high efficacy DMTs, multiple sclerosis, Neurodegenerative Diseases, neurology, neuroscience, patient involvement, personalized therapy, treatment adherenceMultiple Sclerosis Personalized Therapy: 70% Delphi Consensus
An Italian multiple sclerosis Delphi panel reached consensus on 116 of 166…
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alpha-synuclein, Alzheimer’s disease, blood brain barrier, Brain, microplastics, Neurodegenerative Diseases, neuroinflammation, neuroscience, oxidative stress, parkinson’s diseaseMicroplastics and Parkinson’s Disease: 6 Plausible Brain-Risk Pathways
A 2026 mechanistic review linked microplastics to 6 proposed Alzheimer’s disease pathways…
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Alzheimer’s disease, amyloid beta, blood brain barrier, Brain, cerebral blood flow, dementia biomarkers, Neurodegenerative Diseases, neuroscience, neurovascular unit, pericytesAlzheimer’s Neurovascular Unit Dysfunction May Start Before Amyloid
A 2026 review argues that neurovascular-unit dysfunction may precede amyloid-beta generation in…
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autophagy, genetics, lysosomes, neurodegeneration, Neurodegenerative Diseases, neuroscience, parkinson’s disease, potassium channel, proton channel, TMEM175TMEM175 Proton Channel Finding Clarifies Parkinson’s Lysosome Risk
A 2026 PNAS study found that TMEM175 behaves as a pH-sensitive lysosomal…
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action units, Brain, cognition, dementia screening, digital biomarkers, facial expression, mild cognitive impairment, MoCA, Neurodegenerative Diseases, neuroscience, older adults, OpenFaceFacial Markers Differed in 31 Older Adults With MCI-Level MoCA Scores
A 2026 medRxiv preprint found that older adults with mild-cognitive-impairment-level MoCA-J scores…
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autonomic dysfunction, Brain, brain-heart coupling, cognitive screening, ECG, eeg, freezing of gait, heart rate variability, MMSE, Neurodegenerative Diseases, neuroscience, parkinson’s diseaseParkinson’s Brain-Heart Coupling Signals MMSE and Freezing of Gait
A 2026 EEG-ECG preprint reported that beta efficiency-sympathetic coupling differed across healthy…
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caregiver burden, Chinese American caregivers, cultural adaptation, dementia caregivers, dementia stigma, family counseling, KakaoTalk, Korean American caregivers, Neurodegenerative Diseases, NYUCI-ES, Psychiatry, Psychology, therapy, TIDieR, WeChatDementia Caregiver Intervention Needed 24 Cultural Adaptations
A 2026 descriptive study documented 24 major cultural adaptations to the New…
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A4 study, ADNI, Alzheimer’s disease, amyloid PET, blood biomarker, Brain, calibration, cognition, machine learning, negative predictive value, Neurodegenerative Diseases, p-tau217, plasma biomarkersAlzheimer’s Blood Biomarker Models Lose Rule-Out Power Across Cohorts
A 2026 ADNI/A4 validation study found that Alzheimer’s plasma-biomarker machine-learning models still…
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A-beta 42/40, Alzheimer’s disease, amyloid PET, blood biomarkers, Brain, Clarity AD, cognition, GFAP, lecanemab, maintenance dosing, Neurodegenerative Diseases, p-tau181, PK/PD modelingLecanemab Blood Biomarkers Rebound Faster Than Amyloid PET After Stopping
Lecanemab blood biomarkers may rebound much faster than amyloid PET after treatment…
