Neurodegenerative Diseases
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AIP4, Alzheimer’s disease, amyloid beta, APP PS1 mice, Brain, cell cycle re-entry, clomipramine, drug repurposing, Drugs, Itch, memory, Neurodegenerative Diseases, neuronal apoptosisClomipramine Improved Alzheimer’s Mouse Memory by Blocking Itch in 45 Days
A 2026 iScience study found that 45 days of clomipramine improved spatial,…
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Chinese Americans, cognition, cognitive decline, conscientiousness, Dementia, hopelessness, hpa axis, longitudinal cohort, memory decline, Neurodegenerative Diseases, older adults, perceived stress, PINE study, Psychology, StressStress Internalization Predicts Memory Decline in Older Chinese Americans
A 2025 longitudinal analysis of 1,528 older Chinese Americans by Chen et…
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AD/ADRD, Alzheimer’s disease, APOE-e4, Brain, cardiovascular risk, cognitive decline, Dementia, Drugs, Kaiser Permanente, LDL cholesterol, Neurodegenerative Diseases, observational bias, statins, target trial emulationStatins and Dementia Risk: No Long-Term Signal in 322,358 Patients
Statins do not look like a dementia-prevention drug, but they do not…
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basal ganglia, Brain, deep brain stimulation, iTBS, MDS-UPDRS, Neurodegenerative Diseases, Neuromodulation, neuroscience, Neurostimulation, non invasive brain stimulation, parkinson’s disease, putamen, temporal interference stimulation, tTISTranscranial Temporal Interference Stimulation (tTIS) May Improve Parkinson’s Motor Symptoms
Deep brain stimulation works for Parkinson’s, but it requires implanted electrodes. A…
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alpha-synuclein, ambroxol, biomarker, Brain, exenatide, exercise, GLP-1 agonist, Neurodegenerative Diseases, parkinson’s disease, Prevention, prodromal, Psychology, RBD, REM sleep behavior disorder, sleepParkinson’s Disease Prevention: Prodromal Symptoms, RBD, Early Intervention Trials
Parkinson’s disease has a years-to-decades prodromal stage where motor symptoms haven’t yet…
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ADNI, Alzheimer’s disease, amyloid, APOE, APOE-e4, blood biomarker, Brain, cognition, donanemab, Drugs, genetics, lecanemab, longitudinal cohort, mild cognitive impairment, Neurodegenerative Diseases, neuroscience, p-tau217, preclinical ADPlasma p-tau217 Blood Test Predicts Alzheimer’s Risk 1.5x Stronger in APOE-e4
Until recently, Alzheimer’s pathology could only be confirmed in living patients via…
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AD8 screening, Chinese-speaking, cognition, cognitive screening, Dementia, dementia risk screening, immigrant health, language barriers, Mandarin, Neurodegenerative Diseases, older adults, pre-dementia, primary careAD8 Dementia Screening in Chinese-Speaking Older Adults
Brief screening tools for early dementia risk are essential in primary care.…
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antipsychotics, cardiovascular risk, case-control study, cognition, Dementia, Diabetes, Drugs, head injury, integrated care, metabolic syndrome, modifiable risk factors, Neurodegenerative Diseases, Psychiatry, Psychology, psychosis, schizophrenia, smokingSchizophrenia Dementia Risk: Diabetes, Head Injury, Substance Use
Patients with schizophrenia have substantially elevated dementia risk compared to the general…
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Brain, cholinergic, cognition, cognitive fluctuations, Diagnosis, DLB, donepezil, lewy body dementia, Mayo Fluctuations Composite, Neurodegenerative Diseases, neuroleptic sensitivity, neuroscience, Parkinson’s dementia, REM sleep behavior disorder, rivastigmine, sleepLewy Body Dementia Cognitive Fluctuations Affect 75-90% of Patients
Cognitive fluctuations are a defining feature of dementia with Lewy bodies (DLB),…
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agitation, antipsychotics, atypical antipsychotics, cardiovascular disease, CPRD, Dementia, Drugs, FDA black-box warning, matched cohort study, Neurodegenerative Diseases, older adults, Psychiatry, risperidone, side effects, strokeRisperidone Stroke Risk in Dementia: HR 1.28 Across CVD Subgroups
The risperidone-stroke link in dementia is one of the longest-running safety signals…
