Neurodegenerative Diseases
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AB10015, ALS, ALS survival, ALSFRS-R, amyotrophic lateral sclerosis, Drugs, ENCALS, masitinib, mast cells, microglia, motor neuron disease, Neurodegenerative Diseases, neuroscience, riluzole, tyrosine kinase inhibitorMasitinib for ALS: AB10015 Reports 42.3% 5-Year Survival
A 2026 AB10015 post-hoc preprint reported 42.3% 5-year survival from amyotrophic lateral…
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Alzheimer’s disease, amyloid beta, Brain, CD8 T cells, cerebral amyloid angiopathy, CXCL10, CXCR3, microglia, Neurodegenerative Diseases, neuroinflammation, neuroscience, spatial transcriptomics, type I interferonAlzheimer’s Amyloid Plaques Recruit CD8 T Cells Through Type I Interferon
A 2026 single-cell and spatial-transcriptomics study of 21,156 brain immune cells found…
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Brain, exercise, fall risk, fatigue, frailty, multiple sclerosis, Neurodegenerative Diseases, pilot randomized trial, Psychiatry, Psychology, quality of life, rehabilitation, resistance training, therapy, treadmill training, Virtual realityMultiple Sclerosis Frailty Exercise Improved Fatigue in 6 Weeks
A 2026 pilot randomized trial in 16 frail adults with multiple sclerosis…
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ALS, Brain, cerebral palsy, digital biomarkers, dysarthria, HuBERT, motor speech disorder, Neurodegenerative Diseases, neuroscience, parkinson’s disease, phonological subspaces, speech AI, speech biomarkerDysarthria Speech Biomarker Tracked Severity Across 5 Languages
A 2026 medRxiv preprint found that a training-free speech biomarker tracked dysarthria…
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blood biomarkers, Brain, demyelination, disease activity, medRxiv preprint, multiple sclerosis, myelin oligodendrocyte glycoprotein, Neurodegenerative Diseases, neurofilament light chain, neuroscience, relapse, remission, serum MOGSerum MOG Blood Biomarker Rose During Multiple Sclerosis Relapse
A 2026 medRxiv case-control study found that serum myelin oligodendrocyte glycoprotein was…
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ALS biomarkers, ALSFRS-R, amyotrophic lateral sclerosis, cerebrospinal fluid, complement proteins, CSF proteomics, machine learning biomarkers, mass spectrometry, neurodegeneration, Neurodegenerative Diseases, neurofilament light, neuroscienceALS CSF Proteomics Found 399 Candidate Proteins and a 5-Protein Panel
A 2026 cerebrospinal-fluid proteomics preprint involving 87 amyotrophic lateral sclerosis (ALS) patients,…
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ALS, ALSFRS, ALSFRS-R, amyotrophic lateral sclerosis, clinical trial endpoints, functional decline, motor neuron disease, Neurodegenerative Diseases, neuroscience, ordinal outcome scales, PRO-ACT, Psychiatry, Psychology, Shannon entropy, Simpson’s paradoxALS Entropy Analysis Finds 5-Month Signal Hidden by ALSFRS Scores
A 2026 PRO-ACT analysis of amyotrophic lateral sclerosis (ALS) trial data found…
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adverse events, antipsychotics, behavioral symptoms of dementia, BPSD, cardiovascular events, cerebrovascular events, Dementia, Drugs, individual participant data meta-analysis, Neurodegenerative Diseases, older adults, Psychiatry, risperidone, side effectsRisperidone in Dementia Raised Stroke-Related Events 4.11x by Week 4
A 2026 individual participant data meta-analysis of 1,721 dementia trial participants linked…
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Brain, connected speech, dysarthria, hypokinetic dysarthria, language planning, MoCA, Neurodegenerative Diseases, neuroscience, parkinson’s disease, sentence complexity, speech fluency, speech pausesParkinson’s Speech Pauses Track Sentence Complexity and MoCA Scores
A 2026 connected-speech study found that people with Parkinson’s disease produced more…
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AIP4, Alzheimer’s disease, amyloid beta, APP PS1 mice, Brain, cell cycle re-entry, clomipramine, drug repurposing, Drugs, Itch, memory, Neurodegenerative Diseases, neuronal apoptosisClomipramine Improved Alzheimer’s Mouse Memory by Blocking Itch in 45 Days
A 2026 iScience study found that 45 days of clomipramine improved spatial,…
