Neurodegenerative Diseases
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AD/ADRD, Alzheimer’s disease, APOE-e4, Brain, cardiovascular risk, cognitive decline, Dementia, Drugs, Kaiser Permanente, LDL cholesterol, Neurodegenerative Diseases, observational bias, statins, target trial emulationStatins and Dementia Risk: No Long-Term Signal in 322,358 Patients
Statins do not look like a dementia-prevention drug, but they do not…
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basal ganglia, Brain, deep brain stimulation, iTBS, MDS-UPDRS, Neurodegenerative Diseases, Neuromodulation, neuroscience, Neurostimulation, non invasive brain stimulation, parkinson’s disease, putamen, temporal interference stimulation, tTISTranscranial Temporal Interference Stimulation (tTIS) May Improve Parkinson’s Motor Symptoms
Deep brain stimulation works for Parkinson’s, but it requires implanted electrodes. A…
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alpha-synuclein, ambroxol, biomarker, Brain, exenatide, exercise, GLP-1 agonist, Neurodegenerative Diseases, parkinson’s disease, Prevention, prodromal, Psychology, RBD, REM sleep behavior disorder, sleepParkinson’s Disease Prevention: Prodromal Symptoms, RBD, Early Intervention Trials
Parkinson’s disease has a years-to-decades prodromal stage where motor symptoms haven’t yet…
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ADNI, Alzheimer’s disease, amyloid, APOE, APOE-e4, blood biomarker, Brain, cognition, donanemab, Drugs, genetics, lecanemab, longitudinal cohort, mild cognitive impairment, Neurodegenerative Diseases, neuroscience, p-tau217, preclinical ADPlasma p-tau217 Blood Test Predicts Alzheimer’s Risk 1.5x Stronger in APOE-e4
Until recently, Alzheimer’s pathology could only be confirmed in living patients via…
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AD8 screening, Chinese-speaking, cognition, cognitive screening, Dementia, dementia risk screening, immigrant health, language barriers, Mandarin, Neurodegenerative Diseases, older adults, pre-dementia, primary careAD8 Dementia Screening in Chinese-Speaking Older Adults
Brief screening tools for early dementia risk are essential in primary care.…
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Brain, cholinergic, cognition, cognitive fluctuations, Diagnosis, DLB, donepezil, lewy body dementia, Mayo Fluctuations Composite, Neurodegenerative Diseases, neuroleptic sensitivity, neuroscience, Parkinson’s dementia, REM sleep behavior disorder, rivastigmine, sleepLewy Body Dementia Cognitive Fluctuations Affect 75-90% of Patients
Cognitive fluctuations are a defining feature of dementia with Lewy bodies (DLB),…
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agitation, antipsychotics, atypical antipsychotics, cardiovascular disease, CPRD, Dementia, Drugs, FDA black-box warning, matched cohort study, Neurodegenerative Diseases, older adults, Psychiatry, risperidone, side effects, strokeRisperidone Stroke Risk in Dementia: HR 1.28 Across CVD Subgroups
The risperidone-stroke link in dementia is one of the longest-running safety signals…
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exenatide, GLP-1, lixisenatide, network meta-analysis, Neurodegenerative Diseases, neurology, neuroprotection, neuroscience, Ozempic, parkinson’s diseaseCan GLP-1 Drugs Slow Parkinson’s Disease? Evidence from 5 Trials
Research Highlights GLP-1 receptor agonists are diabetes drugs (Ozempic, Trulicity, Byetta) being…
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Alzheimer’s disease, Anxiety, cognition, Dementia, depression, loneliness, meta-analysis, Neurodegenerative Diseases, older adults, social isolation, suicideHow Much Does Loneliness Raise Dementia and Suicide Risk?
Research Highlights Loneliness is associated with substantially elevated risk of both Alzheimer’s…
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bdnf, bdnf gene, dopamine, dopamine neurons, Drugs, gene therapy, genetics, motor behavior, motor symptoms, Neurodegenerative Diseases, parkinson’s disease, pramiprexole, transfectionBDNF Gene Transfection & Pramiprexole Combo Effectively Treat Parkinson’s Disease in Rat Models (2024 Study)
Parkinson’s disease (PD), a degenerative disorder that predominantly affects the motor system,…
