schizophrenia
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complement C4, crispr, CYFIP1, genetics, gwas, IRF8, ITGB2, microglia, MSR1, neuroscience, Psychiatry, schizophrenia, SYK, synaptic pruning, TREM2Schizophrenia Risk Genes Reshape Microglial Pruning in CRISPR Screen
Schizophrenia’s genetic architecture sits awkwardly between neurons and the immune system. A…
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agranulocytosis, antipsychotics, clozapine, Drugs, early intervention, FDA REMS, Finnish registry, first episode psychosis, negative symptoms, Psychiatry, psychosis, relapse prevention, schizophrenia, treatment-resistant schizophreniaEarly Clozapine in Schizophrenia: 34% Lower Relapse Risk
Clozapine has been the most effective antipsychotic in schizophrenia for almost 40…
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amygdala, bipolar disorder, depression, functional connectivity, hippocampus, major depression, neuroscience, Psychiatry, Psychology, resting-state fMRI, schizophrenia, striatum, subcortical connectivity, thalamusSubcortical Connectivity Differs in Schizophrenia, Bipolar, Depression
A 2026 resting-state fMRI study of 800 adults found intra-thalamic hypoconnectivity across…
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clinical staging, depression, early mental illness, genetics, gray matter volume, neuroscience, polygenic risk score, PRONIA, psychiatric biomarkers, Psychiatry, Psychology, psychosis risk, recent-onset depression, recent-onset psychosis, schizophrenia, transdiagnostic severityEarly Mental Illness Severity Tracks Genetics and Brain Volume in PRONIA
A 2026 PRONIA preprint involving 727 discovery-sample participants found that early mental…
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early psychosis, education and employment, first episode psychosis, functional recovery, individual placement and support, NEET, Psychiatry, Psychology, psychosis, psychosis recovery, schizophrenia, schizophrenia spectrum disorders, SEEearly trial, supported education, supported employment, therapy, vocational recoveryEarly Psychosis Vocational Recovery: 53.3% NEET in SEEearly Trial
A 2026 SEEearly baseline report found that 53.3% of 184 young people…
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C677T, folate metabolism, genetics, Han Chinese cohort, homocysteine, metabolic comorbidity, MTHFR, psychiatric genetics, Psychiatry, rs1801133, schizophrenia, type 2 diabetesMTHFR C677T Linked to Schizophrenia With Type 2 Diabetes in Han Chinese
A 2026 Han Chinese case-control preprint linked the MTHFR C677T variant to…
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Brain, cognitive remediation, depression, gamma neuromodulation, GENUS, iTBS, major depressive disorder, meta-analysis, Neurostimulation, schizophrenia, tACS, therapy, theta-burst stimulation, TMS, Tsai labGamma Brain Stimulation Helps Schizophrenia More Than Depression
A 2026 meta-analysis of 56 controlled trials found the clearest gamma-frequency neuromodulation…
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5-HT7, acute psychosis, antipsychotics, d2 receptor, Drugs, JEWEL trial, lurasidone, negative symptoms, Neurotransmitters, PANSS, positive symptoms, Psychiatry, psychosis, schizophreniaLurasidone Improves Positive Symptoms of Schizophrenia More Than Negative
Lurasidone is approved for schizophrenia and bipolar depression on the strength of…
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anhedonia, Black Americans, CBT for psychosis, defeatist beliefs, mediation analysis, microaggressions, negative symptoms, PANSS, Psychiatry, Psychology, psychosis, racial discrimination, racial stress, schizophrenia, therapyBlack Americans Diagnosed with Schizophrenia 2.42x the Rate of White Americans: More Negative Symptoms
Black Americans are diagnosed with schizophrenia-spectrum disorders at 2.42 times the rate…
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anti-ribosomal P, antiphospholipid antibodies, autoimmune, complement, first episode psychosis, lupus, neuropsychiatric lupus, NPSLE, Psychiatry, psychosis, schizophrenia, SLELupus Psychosis: 4.5% Prevalence and Antibody Predictors
Research Highlights Across 65 studies and 31,495 lupus patients, 4.5% develop psychosis…
