GLOOM
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Brain, brain aging, cognition, cognitive aging, crp, cytokines, diffusion mri, Healthy Minds for Life, inflammation, neuroscience, NODDI, vascular risk, white matterInflammation Tracks White-Matter MRI in Aging Adults
Chronic low-grade inflammation rises with age, and a growing body of work…
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18F-DOPA PET, antipsychotics, Brain, caudate, dopamine, dopamine hypothesis, Drugs, longitudinal, neuroimaging, neuroscience, Neurotransmitters, psychosis, relapse, remission, schizophrenia, striatumStriatal Dopamine Drops From Psychosis to Schizophrenia Remission
The dopamine hypothesis of schizophrenia is the field’s longest-running mechanistic story, and…
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AMPA receptor, antidepressants, Brain, chronic mild stress, comorbidity, depression, Drugs, GluA1, glutamate, ketamine, neuroscience, Neurotransmitters, PTSD, rat model, single prolonged stress, Stress, synaptic plasticityPTSD With Depression Hits AMPA Receptors Harder in Rat Models
PTSD and major depressive disorder co-occur in roughly half of patients with…
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anhedonia, Black Americans, CBT for psychosis, defeatist beliefs, mediation analysis, microaggressions, negative symptoms, PANSS, Psychiatry, Psychology, psychosis, racial discrimination, racial stress, schizophrenia, therapyBlack Americans Diagnosed with Schizophrenia 2.42x the Rate of White Americans: More Negative Symptoms
Black Americans are diagnosed with schizophrenia-spectrum disorders at 2.42 times the rate…
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agitation, antipsychotics, atypical antipsychotics, cardiovascular disease, CPRD, Dementia, Drugs, FDA black-box warning, matched cohort study, Neurodegenerative Diseases, older adults, Psychiatry, risperidone, side effects, strokeRisperidone Stroke Risk in Dementia: HR 1.28 Across CVD Subgroups
The risperidone-stroke link in dementia is one of the longest-running safety signals…
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anticoagulants, antidepressants, Anxiety, atrial fibrillation, bleeding, case-crossover, cohort study, depression, DOACs, drug interactions, Drugs, gastrointestinal bleeding, Interactions, intracranial hemorrhage, ssrisSSRIs + DOACs: No Excess Bleeding vs. Other Antidepressants
SSRIs raise bleeding risk on their own. DOACs (direct oral anticoagulants —…
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bipolar disorder, cardiac malformations, cohort study, Drugs, Ebstein anomaly, lithium, mood stabilizers, NICE guidelines, perinatal, postpartum psychosis, postpartum relapse, pregnancy, PsychiatryLithium in Pregnancy: Why Late Discontinuation Backfires
Lithium prescribing during pregnancy sits in a knot of competing risks. The…
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Autism, Danish registers, familial confounding, genetics, indirect genetic effects, iPSYCH, maternal health, Mendelian randomization, pregnancy, Psychiatry, sibling comparison, ssris, valproateMaternal Health and Autism Risk: Most Links Are Genetic, Not Prenatal
For two decades, headlines have linked autism to maternal obesity, depression, anxiety,…
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abuse liability, addiction, case report, depression, Drugs, esketamine, ketamine, ketamine cystitis, nmda antagonist, Psychiatry, R-ketamine, S-ketamine, Spravato, suicidality, suicide, treatment-resistant depressionKetamine Addiction After One Therapeutic Dose: How Rare Is It?
Research Highlights One published case is not a base rate. Roelandt and…
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addiction, alcohol, alcohol addiction, alcohol consumption, alcohol dependence, alcohol intake, alcoholism, bilateral superior frontal gyrus, Brain, brain structure, brain volume, cognition, cognitive decline, cognitive function, cortical thickness, drinking, Drugs, effects of alcohol, elderly, frontal lobe, gray matter, heavy drinking, older adults, prefrontal cortex, right lateral occipital cortex, right precentral gyrus, side effects, subcortical volume, Sweden, white matterAlcohol & Brain Volume in Older Adults: Cortical Thinning & White Matter Loss in Heavy Drinkers (250g/Week) (2023 Study)
Alcohol’s effects on the brain, especially among the elderly, have long been…
