Alzheimer’s disease
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Alzheimer’s disease, Brain, chromatin remodeling, iPSC neurons, Lamin B receptor, Lamin B2, Neurodegenerative Diseases, neuroscience, nuclear lamina, PS19 mice, pTau217, tau oligomers, tauopathyTau Oligomers Disrupted Nuclear Lamina in Alzheimer’s Disease Models
A 2026 Acta Neuropathologica study found that oligomeric tau was linked to…
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Alzheimer’s disease, amyloid beta, autophagy, genetics, lysosomes, mouse models, NDST3, Neurodegenerative Diseases, neuroscience, tau pathology, V-ATPaseNDST3 Suppression Restores Lysosome Acidity in Alzheimer’s Mouse Models
A 2026 mechanistic Alzheimer’s study found that suppressing NDST3 shifted lysosomal pH…
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ADNI, Alzheimer’s disease, ANA-GNN, artificial-intelligence, Brain, clinical decision support, cognition, dementia diagnosis, graph neural network, hippocampus, machine learning, mild cognitive impairment, Neurodegenerative Diseases, neuroimaging, neuroscience, posterior cingulate cortex, structural MRIAlzheimer’s AI MRI Diagnosis: ANA-GNN Reaches 85.23% Accuracy in ADNI
A 2026 ADNI study reported 85.23% accuracy for ANA-GNN, a graph neural…
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Alzheimer’s disease, amyloid beta, Brain, CD8 T cells, cerebral amyloid angiopathy, CXCL10, CXCR3, microglia, Neurodegenerative Diseases, neuroinflammation, neuroscience, spatial transcriptomics, type I interferonAlzheimer’s Amyloid Plaques Recruit CD8 T Cells Through Type I Interferon
A 2026 single-cell and spatial-transcriptomics study of 21,156 brain immune cells found…
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AIP4, Alzheimer’s disease, amyloid beta, APP PS1 mice, Brain, cell cycle re-entry, clomipramine, drug repurposing, Drugs, Itch, memory, Neurodegenerative Diseases, neuronal apoptosisClomipramine Improved Alzheimer’s Mouse Memory by Blocking Itch in 45 Days
A 2026 iScience study found that 45 days of clomipramine improved spatial,…
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AD/ADRD, Alzheimer’s disease, APOE-e4, Brain, cardiovascular risk, cognitive decline, Dementia, Drugs, Kaiser Permanente, LDL cholesterol, Neurodegenerative Diseases, observational bias, statins, target trial emulationStatins and Dementia Risk: No Long-Term Signal in 322,358 Patients
Statins do not look like a dementia-prevention drug, but they do not…
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ADNI, Alzheimer’s disease, amyloid, APOE, APOE-e4, blood biomarker, Brain, cognition, donanemab, Drugs, genetics, lecanemab, longitudinal cohort, mild cognitive impairment, Neurodegenerative Diseases, neuroscience, p-tau217, preclinical ADPlasma p-tau217 Blood Test Predicts Alzheimer’s Risk 1.5x Stronger in APOE-e4
Until recently, Alzheimer’s pathology could only be confirmed in living patients via…
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Alzheimer’s disease, Anxiety, cognition, Dementia, depression, loneliness, meta-analysis, Neurodegenerative Diseases, older adults, social isolation, suicideHow Much Does Loneliness Raise Dementia and Suicide Risk?
Research Highlights Loneliness is associated with substantially elevated risk of both Alzheimer’s…
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ageing, Alzheimer’s disease, Biological Psychiatry, causality, CHARLS, chronotype, circadian rhythm, cognition, cognitive ageing, cognitive decline, cohort study, Dementia, Editor Eimear Foley, insomnia, mild cognitive impairment, modifiable risk factors, napping, neurodegenerative disease, older adult, sleep, sleep disorders, sleep disturbance, sleep hygiene, sleep problems, sleep quality, UK BiobankChanging sleep patterns linked to cognitive decline and dementia
Sleep is essential for both physical and mental health. Not getting the…
