genetics
-
depression, Diet & Nutrition, genetics, iq, late diagnosis, metabolic control, newborn screening, phenylalanine, phenylketonuria, PKU children, Psychiatry, quality of life, suicidal thoughtsLate-Diagnosed PKU Linked to Depression in Children
A 2026 Egyptian study of 76 children found a sharp mental-health gradient…
-
clinical staging, depression, early mental illness, genetics, gray matter volume, neuroscience, polygenic risk score, PRONIA, psychiatric biomarkers, Psychiatry, Psychology, psychosis risk, recent-onset depression, recent-onset psychosis, schizophrenia, transdiagnostic severityEarly Mental Illness Severity Tracks Genetics and Brain Volume in PRONIA
A 2026 PRONIA preprint involving 727 discovery-sample participants found that early mental…
-
Alzheimer’s disease, amyloid beta, autophagy, genetics, lysosomes, mouse models, NDST3, Neurodegenerative Diseases, neuroscience, tau pathology, V-ATPaseNDST3 Suppression Restores Lysosome Acidity in Alzheimer’s Mouse Models
A 2026 mechanistic Alzheimer’s study found that suppressing NDST3 shifted lysosomal pH…
-
ALS mechanisms, C9orf72 ALS, deferiprone, ferroptosis, genetics, GPX4, motor neurons, Neurodegenerative Diseases, neuroscience, Nrf2, poly-GR, Slc7a11C9orf72 ALS Poly-GR Drives Ferroptosis via Nrf2-Slc7a11
A 2026 Cell & Bioscience study found that poly-GR, one of the…
-
aMT6s, Brain, circadian rhythm, genetics, genome-wide association study, Hormones, melatonin, MTNR1B, multi-ancestry GWAS, polygenic risk score, sleep, sleep duration, type 2 diabetes, urinary biomarkerMelatonin aMT6s GWAS Found No Hits, PRS Linked to Sleep and Diabetes
A 2026 multi-ancestry genome-wide association study of urinary aMT6s, a melatonin metabolite…
-
antidepressants, cyp2c19, depression, DIVERGE, genetics, major depressive disorder, Pakistan, pharmacogenetics, polypharmacy, Psychiatry, psychotherapy access, social support, treatment-resistant depressionTreatment-Resistant Depression in Pakistan: 34% TRD, 86% Polypharmacy
A 2026 DIVERGE analysis of 3,677 antidepressant-exposed patients with major depressive disorder…
-
Anxiety, copy number variants, DLGAP1, genetics, MAPK8IP3, neuroscience, NPY5R, obsessive compulsive disorder, OCD genetics, pedigrees, polygenic risk scores, Psychiatry, rare variants, whole-genome sequencingRare OCD Variants in NPY5R, DLGAP1, and MAPK8IP3 Segregate in Families
A 2026 whole-genome sequencing preprint found rare variant signals in 2 multiplex…
-
C677T, folate metabolism, genetics, Han Chinese cohort, homocysteine, metabolic comorbidity, MTHFR, psychiatric genetics, Psychiatry, rs1801133, schizophrenia, type 2 diabetesMTHFR C677T Linked to Schizophrenia With Type 2 Diabetes in Han Chinese
A 2026 Han Chinese case-control preprint linked the MTHFR C677T variant to…
-
Anxiety, childhood anxiety, default mode network, dmn, dna methylation, epigenetics, fMRI, genetics, GUSTO cohort, limbic network, MASC-2, neuroscience, Psychiatry, Psychology, sex differencesChildhood Anxiety Linked to DNA Methylation and DMN-Limbic Development
A 2026 Singapore birth-cohort preprint found a conditional childhood-anxiety signal: the cord-blood…
-
ADNI, Alzheimer’s disease, amyloid, APOE, APOE-e4, blood biomarker, Brain, cognition, donanemab, Drugs, genetics, lecanemab, longitudinal cohort, mild cognitive impairment, Neurodegenerative Diseases, neuroscience, p-tau217, preclinical ADPlasma p-tau217 Blood Test Predicts Alzheimer’s Risk 1.5x Stronger in APOE-e4
Until recently, Alzheimer’s pathology could only be confirmed in living patients via…
